Pneumonologie

, Volume 146, Issue 4, pp 307–320 | Cite as

Intermittent chemotherapy in pulmonary tuberculosis — Current aspects

  • Marian Zierski
Article

Abstract

A critical review of the application of various methods of intermittent chemotherapy in the initial treatment of tuberculosis and retreatment of far advanced pulmonary tuberculosis has been presented.

Not all drugs are suitable for intermittent chemotherapy in clinical practice, but the introduction in the last years of new drugs in the treatment of tuberculosis, especially rifampicin and ethambutol made possible the application of intermittent chemotherapy also for the groups of patients with far advanced chronic pulmonary tuberculosis with resistant bacilli. For intermittent chemotherapy isoniazid, rifampicin, ethambutol and streptomycin are particularly suitable in clinical practice. The intermittent chemotherapy should be applied only under strict supervision, as it requires a very good monitoring organization system. Still some problems of intermittent chemotherapy in tuberculosis are unsolved and require further studies, but the perspectives of this type of treatment seems to be very promising.

Keywords

Tuberculosis Streptomycin Rifampicin Initial Treatment Critical Review 

Zusammenfassung

Es wird ein kritischer Überblick über die Anwendung verschiedener Formen der intermittierenden Chemotherapie bei unvorbehandelten und bei vorbehandelten Tuberkulosen gegeben. Nicht alle antituberkulösen Mittel eignen sich für eine intermittierende Chemotherapie, doch hat die Neueinführung von Tuberkulose-Medikamenten in den letzten Jahren, insbesondere von Rifampicin und Ethambutol, die Anwendung einer intermittierenden Chemotherapie auch für Patienten mit weit fortgeschrittener, bakteriologisch resistenter Tuberkulose möglich gemacht. Für intermittierende Chemotherapie eignen sich besonders Isoniazid, Rifampicin, Ethambutol und Streptomycin. Die intermittierende Chemotherapie darf nur unter strenger Überwachung angewendet werden. Sie erfordert eine minutiöse Organisation der Kontrollen. Obwohl noch einige Probleme einer intermittierenden Chemotherapie der Tuberkulose ungelöst sind und weiterer Untersuchungen bedürfen, scheint diese Behandlungsform doch vielversprechend zu sein.

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Marian Zierski
    • 1
  1. 1.Department of Respiratory Diseases and Tuberculosis Postgraduate Medical SchoolHospital for Lung DiseasesŁódźPoland

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