Journal of Molecular Evolution

, Volume 29, Issue 3, pp 212–222 | Cite as

The Muridae glyceraldehyde-3-phosphate dehydrogenase family

  • S. Riad-El Sabrouty
  • J-M Blanchard
  • L. Marty
  • P. Jeanteur
  • M. Piechaczyk


Although only one gene is known to be functional, numerous glyceraldehyde-3-phosphate dehydrogenase (GAPDH) related sequences are scattered throughoutMus musculus andRattus rattus genomes. In this report we show that: (1) GAPDH pseudogenes are repeated to comparable extents, at least 400 copies, in 12 other Muridae species; (2) the complete, or nearly so, sequence of GAPDH messenger RNA is amplified, and a high proportion, if not all of these copies, are intronless; (3) GAPDH pseudogenes are preferentially located in heavily methylated and DNAse I-insensitive regions of chromatin; and (4) the presence of atypical GAPDH-related mRNAs in different cellular contexts raises the possibility that more than one GAPDH gene is transcribed.

Key words

Pseudogenes Amplification Retroposition Chromatin structure DNA methylation Transcription RNA 


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Copyright information

© Springer-Verlag New York Inc 1989

Authors and Affiliations

  • S. Riad-El Sabrouty
    • 1
    • 2
  • J-M Blanchard
    • 1
    • 2
  • L. Marty
    • 1
    • 2
  • P. Jeanteur
    • 1
    • 2
  • M. Piechaczyk
    • 1
    • 2
  1. 1.UA CNRS 1191, Laboratoire de Biologie MoléculaireUSTLMontpellier CedexFrance
  2. 2.Laboratoire de BiochimieCentre Paul LamarqueMontpellier CedexFrance

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