Digestive Diseases and Sciences

, Volume 41, Issue 12, pp 2383–2391 | Cite as

Brain ischemia and gastric mucosal damage in spontaneously hypertensive rats

The role of arterial vagal adrenoceptors
  • Keishi Kawakubo
  • Setsuro Ibayashi
  • Tetsuhiko Nagao
  • Kosei Doi
  • Kunihiko Aoyagi
  • Mitsuo Iida
  • Seizo Sadoshima
  • Masatoshi Fujishima
Esophageal, Gastric, And Duodenal Disorders


Brain ischemia is often accompanied by acute gastric lesions. To clarify the underlying mechanism, the influence of acute ischemic insult to the brain on gastric hemodynamics and mucosal integrity was examined in spontaneously hypertensive rats. One hour after brain ischemia, gastric mucosal blood flow decreased to 71% of the preischemic levels in the control rats but was preserved significantly better, at 94 and 108%, in the prazosin-treated and guanethidine-treated rats, respectively. Vagotomy almost abolished the decrease in gastric mucosal blood flow during cerebral ischemia. Intragastric 0.6 N hydrochloric acid administered just after reperfusion induced more severe hemorrhagic ulcers in the control than in the prazosin-treated and vagotomized groups. These results suggest that noradrenergic neurons acting through α1-adrenoceptors contributes to the decrease in gastric mucosal blood flow, and the subsequent disturbed integrity of the gastric mucosa, through the vagal adrenergic pathway during brain ischemia in spontaneously hypertensive rats.

Key words

brain ischemia gastric mucosal blood flow integrity of the gastric mucosa vagal adrenergic pathway 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Keishi Kawakubo
    • 1
  • Setsuro Ibayashi
    • 1
  • Tetsuhiko Nagao
    • 1
  • Kosei Doi
    • 1
  • Kunihiko Aoyagi
    • 1
  • Mitsuo Iida
    • 1
  • Seizo Sadoshima
    • 1
  • Masatoshi Fujishima
    • 1
  1. 1.Second Department of Internal Medicine, Faculty of MedicineKyushu UniversityFukuokaJapan

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