Digestive Diseases and Sciences

, Volume 41, Issue 12, pp 2343–2347 | Cite as

Primary CD30 (Ki-1)-positive anaplastic large cell lymphoma of the duodenum

  • Ichiro Yoshikawa
  • Ikuo Murata
  • Yumi Tanaka
  • Kenji Kanagawa
  • Akinari Tabaru
  • Hideaki Itoh
  • Makoto Otsuki
Case Report

Summary

Ki-1 anaplastic large cell lymphoma (ALCL) commonly affects the skin, lymph nodes, and bone. Primary ALCL of the alimentary tract is rare. The authors describe a case of primary ALCL of the duodenum in a 62-year-old man who presented with epigastric discomfort and weight loss. The patient was treated with modified CHOP and is in complete remission at 18 months. We reviewed all cases of primary ALCL of the alimentary tract in the literature and noted that this neoplasm often mimics gastrointestinal carcinoma.

Key words

duodenal lymphoma anaplastic large cell lymphoma immunohistochemistry Ki-1 positive CD30 antigen extranodal lymphoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Stein H, Gerdes J, Schwab U, Lemke H, Mason DY, Ziegler A, Schienle W, Diehl V: Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly-detected small cell population. Int J Cancer 30:445–449, 1982PubMedGoogle Scholar
  2. 2.
    Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858, 1985PubMedGoogle Scholar
  3. 3.
    Rivano MT, Falini B, Stein H, Canino S, Ciani C, Gerdes J, Ribacchi R, Gobbi M, Pileri S: Histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi's lymphadenitis): Morphological and immunohistochemical study of 8 cases. Histopathology 11:1013–1027, 1987PubMedGoogle Scholar
  4. 4.
    Agnarsson BA, Kadin ME: Ki-1 positive large cell lymphoma: A morphologic and immunologic study of 19 cases. Am J Surg Pathol 12:264–274, 1988PubMedGoogle Scholar
  5. 5.
    Schnitzer B, Roth MS, Hyder DM, Ginsburg D: Ki-1 lymphomas in children. Cancer 61:1213–1221, 1988PubMedGoogle Scholar
  6. 6.
    Kadin ME, Sako D, Berliner N, Franklin W, Woda B, Borowitz M, Ireland K, Schweid A, Herzog P, Lange B, Dorfman R: Childhood Ki-1 lymphoma presenting with skin lesions and peripheral lymphadenopathy. Blood 68:1042–1049, 1986PubMedGoogle Scholar
  7. 7.
    Chan JKC, Ng CS, Leung TW, Lo ESF, Lau WH, Mcguire: Anaplastic large cell Ki-1 lymphoma. Delineation of two morphological types. Histopathology 15:11–34, 1989PubMedGoogle Scholar
  8. 8.
    Chott A, Kaserer K, Augustin I, Vesely M, Heintz R, Oehlinger W, Hanak H, Radaszkiewicz T: Ki-1-positive large cell lymphoma. A clinicopathologic study of 41 cases. Am J Surg Pathol 14:439–448, 1990PubMedGoogle Scholar
  9. 9.
    Moubayed P, Kaiserling E, Stein H: T-cell lymphomas of the stomach: Morphological and immunological studies characterizing two cases of T-cell lymphoma. Virchows Arch A 411:523–529, 1987Google Scholar
  10. 10.
    Salhany KE, Collins RD, Greer JP, Kinny MC: Long-term survival in Ki-1 lymphoma. Cancer 67:516–522, 1991PubMedGoogle Scholar
  11. 11.
    Pearson JM, Borg-Grech A: Primary Ki-1 (CD30)-positive, large cell, anaplastic lymphoma of the esophagus. Cancer 68:418–421, 1991PubMedGoogle Scholar
  12. 12.
    Taccagni GL, Terreni MR, Rovere E: Anaplastic large cell Ki-1 lymphoma of the stomach with villopodal projections: An immunocytochemical and ultrastructural study and review of the literature. Ultrastruct Pathol 16:291–302, 1992PubMedGoogle Scholar
  13. 13.
    Ng K, Thatcher G, Trotter J, Marshall E, Metcalf C: Extranodal Ki-1 lymphoma in a renal transplant patient. Aust NZ J Med 22:51–53, 1992Google Scholar
  14. 14.
    Ross CW, Hanson CA, Schnitzer B: CD30 (Ki-1)-positive, anaplastic large cell lymphoma mimicking gastrointestinal carcinoma. Cancer 70:2517–2523, 1992PubMedGoogle Scholar
  15. 15.
    Paulli M, Rosso R, Kindl S, Boveri E, Bonoldi E, Stracca V, Motta T, Arrigoni G, Lazzarino M, Menestrina F, Magrini U: Primary gastric CD30 (Ki-1)-positive large cell non-Hodgkin's lymphomas. A clinicopathologic analysis of six cases. Cancer 73:541–549, 1994PubMedGoogle Scholar
  16. 16.
    Gustmann C, Altmannsberger M, Osborn M, Griesser H, Feller AC: Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas. Am J Pathol 133:1413–1422, 1991Google Scholar
  17. 17.
    Burns BF, Dardick I: Ki-1 positive non-Hodgkin's lymphomas. An immunophenotypic, ultrastructural, and morphometric study. Am J Clin Pathol 93:327–332, 1990PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Ichiro Yoshikawa
    • 1
    • 2
  • Ikuo Murata
    • 1
    • 2
  • Yumi Tanaka
    • 1
    • 2
  • Kenji Kanagawa
    • 1
    • 2
  • Akinari Tabaru
    • 1
    • 2
  • Hideaki Itoh
    • 1
    • 2
  • Makoto Otsuki
    • 1
    • 2
  1. 1.From the Third Department of Internal Medicine and First Department of SurgeryUniversity of Occupational and Environmental HealthJapan
  2. 2.School of MedicineKitakyushuJapan

Personalised recommendations