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Scrambled duplications in the feline leukemia virusgag gene: A putative pattern for molecular evolution

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Summary

The present study is a detailed computer-assisted analysis of the feline leukemia virus gag gene nucleotide sequence together wit its flanking sequences (ST-FeLV GAG) that is compared with the aligned sectors of the Moloney strain of murine leukemia virus (Mo-MuLV GAG) and of three strains of feline sarcoma virus. It shows that perfectly matched repeated oligomers up to 13 nucleotides long are overrepresented and scattered throughout both ST-FeLV GAG and Mo-MuLV GAG, in noncoding and coding sectors, with no stringent correlation to codon usage in ST-FeLV gPr80gag. Many repeated oligomers share a core consensus that is intriguingly part of the inverted repeat at the termini of the long terminal repeat. Local scrambled repetitions of nucleotide subsequences have been found; they suggest a model of molecular evolution byslippage-like mechanisms. Thus, viral genomes could be subject to the same evolutionary mechanisms that are now known to be operating extensively in eukaryotic genomes. The data are discussed in light of putative patterns of molecular evolution.

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Authors and Affiliations

  1. Laboratoire d'Hématologie Expérimentale (CNRS)., Centre Hayem, Hôpital Saint-Louis, 7575, Paris Cédex 10, France

    Ivan Laprevotte

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  1. Ivan Laprevotte
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Laprevotte, I. Scrambled duplications in the feline leukemia virusgag gene: A putative pattern for molecular evolution. J Mol Evol 29, 135–148 (1989). https://doi.org/10.1007/BF02100112

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  • DOI: https://doi.org/10.1007/BF02100112

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