Summary
The ribosome is proposed to have evolved from an earlier RNA-replisome, which synthesized RNA. Ancestral tRNA molecules originally were loaded with trinucleotide sequences and donated them to growing RNA chains. The enzymatic addition of the C-C-A trinucleotide to presentday transfer RNA molecules is a carryover from this function. The strategies of reading RNA sequences by triplet codons and of housing information genetically in special repository molecules predates the origin of protein and DNA. These latter two polymers arose together at the time when the RNA replisome was converted to a ribosome.
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References
Altman S (1989) Ribonuclease P: an enzyme with a catalytic RNA subunit. Adv Enzymol 62:1–36
Arai K-I, Low RL, Kornberg A (1981) Movement and site selection for priming by the primosome in phage phiX174 DNA. Proc Natl Acad Sci USA 78:707–711
Benner SA, Allemann RK, Ellington AD, Ge L, Glasfeld A, Leanz GF, Krauch T, MacPherson LJ, Moroney S, Piccirilli JA (1987) Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry. In Symposia on quantitative biology, vol 52. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, pp 53–63
Benner SA, Ellington AD, Tauer A (1989) Modern metabolism as a palimpsest of the RNA world. Proc Natl Acad Sci USA 86:7054–7058
Bloch DP (1988) Cybernetic origins of replication. Orig Life Evol Biosphere 18:87–96
Cech TR, Bass BL (1986) Biological catalysis by RNA. Annu Rev Biochem 55:599–629
Cedergren R, Grosjean H (1987) On the primacy of primordial RNA. Biosystems 20:175–180
Crick FHC (1968) The origin of the genetic code. J Mol Biol 38:367–379
Deutscher MP (1973) Synthesis and function of the-C-C-A terminus of transfer RNA. Prog Nucleic Acid Res Mol Biol 13:51–92
Edwards MR (1989) A possible origin of RNA catalysis in multienzyme complexes. Orig Life Evol Biosphere 19:69–72
Gibson TJ, Lamond AI (1990) Metabolic complexity in the RNA world and implications for the origin of protein synthesis. J Mol Evol 30:7–15
Green PJ, Pines O, Inouye M (1986) The role of antisense RNA in gene regulation. Annu Rev Biochem 55:569–597
Guerrier-Takada C, Altman S (1989) Specific interactions in RNA enzyme-substrate complexes. Science 246:1578–1584
Lazcano A, Guerrero R, Margulis L, Oro J (1988) The evolutionary transition from RNA to DNA in early cells. J Mol Evol 27:283–290
McSwiggen JA, Cech TR (1989) Stereochemistry of RNA cleavage by theTetrahymena ribozyme and evidence that the chemical step is not rate-limiting. Science 244:679–683
Melton DA (ed) (1988) Antisense RNA and DNA. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, 149 p
Priano C, Dramer FR, Mills DR (1987) Evolution of the RNA coliphages: the role of secondary structure during RNA replication. In Symposia on quantitative biology, vol 52. Cold Spring Harbor Laboratories, Cold Spring Harbor NY, pp 321–330
Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Ehrlich HA, Arnheim N (1985) Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350–1354
Weiner AM (1988) Eukaryotic nuclear telomeres: molecular fossils of the RNP world? Cell 52:155–158
Weiner AM, Maizels N (1987) tRNA-like structures tag the 3′ ends of genomic RNA molecules for replication: implications for the origin of protein synthesis. Proc Natl Acad Sci USA 84:7383–7387
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Campbell, J.H. An RNA replisome as the ancestor of the ribosome. J Mol Evol 32, 3–5 (1991). https://doi.org/10.1007/BF02099922
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DOI: https://doi.org/10.1007/BF02099922