Acta diabetologia latina

, Volume 18, Issue 2, pp 107–114 | Cite as

The effects of cyproheptadine on glucose tolerance and pancreatic islets in rats

  • Ryuichi Kikkawa
  • Danielle Duvillard
  • Werner Stauffacher
Original Contributions


The effects of cyproheptadine (CPH) on plasma levels, of glucose, insulin and glucagon were studied in rats in order to clarify the diabetogenicity of this compound. CPH was given to the rats at a daily dose of 45 mg per kg body weight via gastric intubation for up to 20 days. Glucose intolerance appeared after 5 days of CPH treatment without significant increase in fasting glucose level. Plasma insulin response to glucose loading was depressed in the early phase of the glucose tolerance test in groups treated for 10 and 20 days. In these groups the insulinogenic index was significantly lowered. Pancreatic insulin content decreased rapidly after single dose of CPH. Plasma level and pancreatic content of glucagon were not changed by this compound. These results suggested that chronic treatment with CPH caused glucose intolerance in rats through its direct influence on pancreatic B-cell function.


Cyproheptadine Diabetogenic compound Oral glucose tolerance test Pancreatic insulin and glucagon content 


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Copyright information

© Casa Editrice 1981

Authors and Affiliations

  • Ryuichi Kikkawa
    • 1
  • Danielle Duvillard
    • 1
  • Werner Stauffacher
    • 1
  1. 1.Medizinische Universitätsklinik Inselspital BernDeutschland

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