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In vitro activity of azithromycin and tetracycline against 358 clinical isolates ofBrucella melitensis

  • New Antimicrobial Agents
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Abstract

The in vitro activity of azithromycin against human pathogenic strains ofBrucella melitensis was tested at three centres and compared to that of tetracycline, the standard antibiotic currently used for the treatment of human brucellosis. MIC determination was carried out. Tested concentration ranges for both azithromycin and tetracycline were between 0.03 and 16 µg/ml.Brucella melitensis biotype 1, strain M16 was employed as a control microorganism. A total of 358Brucella melitensis strains from human blood cultures were tested. MIC90 (µg/ml) values ranged from 0.5 to 1.00 for azithromycin and were 0.25 for tetracycline. It was concluded that there was little difference in the sensitivity of pathogenicBrucella melitensis to azithromycin and tetracycline isolated from three different regions in Spain. These results encourage further investigations on the possible therapeutic role of azithromycin in brucellosis.

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Authors and Affiliations

  1. Departamento de Microbiología, Facultad de Medicina, Universidad de Valladolid, Ramon y Cajal, 7, 47005, Valladolid, Spain

    R. Landínez

  2. Departamento de Microbiología, Hospital “Príncipes de España”, Hospitalet de Llobregat, Barcelona, Spain

    J. Liñares & R. Martín

  3. Departamento de Microbiología, Hospital “Ramón y Cajal”, Madrid, Spain

    E. Loza, J. Martínez-Beltrán & F. Baquero

Authors
  1. R. Landínez
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  2. J. Liñares
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  3. E. Loza
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  4. J. Martínez-Beltrán
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  5. R. Martín
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  6. F. Baquero
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Landínez, R., Liñares, J., Loza, E. et al. In vitro activity of azithromycin and tetracycline against 358 clinical isolates ofBrucella melitensis . Eur. J. Clin. Microbiol. Infect. Dis. 11, 265–267 (1992). https://doi.org/10.1007/BF02098096

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  • DOI: https://doi.org/10.1007/BF02098096

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