Abstract
The effect of antimicrobial agent active against anaerobes, gram-positive cocci and fungi on the uptake of ciprofloxacin by human neutrophils (PMNs) was evaluated. In the presence of therapeutic extracellular concentrations of these agents, ciprofloxacin reached high intracellular concentrations [cellular-to-extracellular ratio (C/E) ≥ 2.9], this value being higher in the presence of amphotericin B (C/E 6.3 ± 0.9). The intracellular penetration of ciprofloxacin was higher when PMNs were stimulated with opsonized zymosan (C/E ≥ 5.6). In summary, none of the antimicrobial agents tested significantly impaired the uptake of ciprofloxacin by human PMNs.
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García, I., Pascual, A. & Perea, E.J. Effect of several antimicrobial agents on ciprofloxacin uptake by human neutrophils. Eur. J. Clin. Microbiol. Infect. Dis. 11, 260–262 (1992). https://doi.org/10.1007/BF02098094
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DOI: https://doi.org/10.1007/BF02098094