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Synergism of trimethoprim and ciprofloxacin in vitro against clinical bacterial isolates

  • P. Huovinen
  • J. S. Wolfson
  • D. C. Hooper
Notes

Abstract

For the first time, the effects of combinations of trimethoprim and a fluoroquinolone (ciprofloxacin) against gram-positive and gram-negative bacterial isolates were evaluated in vitro. Synergism was found in 31 % (fractional inhibitory concentration, FIC) and 33 % (fractional bactericidal concentration, FBC) of 121 clinical isolates of various bacterial strains, most often inEscherichia coli, staphylococci, and enterococci. Antagonism occurred in 1 % (FIC) and 3 % (FBC). The combination of trimethoprim and ciprofloxacin merits further evaluation for potential usefulness as a clinical regimen.

Keywords

Internal Medicine Bacterial Strain Inhibitory Concentration Clinical Isolate Fluoroquinolone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Venlagsgesellschaft mbH 1992

Authors and Affiliations

  • P. Huovinen
    • 1
    • 2
  • J. S. Wolfson
    • 1
    • 2
    • 3
  • D. C. Hooper
    • 3
  1. 1.Department of Medical MicrobiologyTurku UniversityTurkuFinland
  2. 2.Antimicrobial Research UnitNational Public Health InstituteTurkuFinland
  3. 3.Infectious Disease Unit, Medical ServicesMassachusetts General HospitalBostonUSA

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