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Spontaneously occurring staphylococcal mutants resistant to clinically achievable concentrations of ciprofloxacin and temafloxacin

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Abstract

The frequency of spontaneously occurring mutants resistant to 0.5, 1, 2, 4 and 8 µg of temafloxacin or ciprofloxacin per milliliter was documented with fourStaphylococcus aureus and fourStaphylococcus epidermidis strains. Resistant mutants were recovered at two- to four-fold the MIC of either drug, and they displayed cross-resistance to other fluoroquinolones. Resistance to temafloxacin occurred at frequencies lower than those observed with equal concentrations of ciprofloxacin. Resistance to greater than four-fold the MIC of either drug was not detected (frequencies < 10−10).

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Authors and Affiliations

  1. The Clinical Microbiology Institute, PO Box 947, 97062, Tualatin, Oregon, USA

    A. L. Barry

  2. Oregon Health Sciences University, 97201, Portland, Oregon, USA

    M. A. Pfaller

  3. St. Vincent Hospital and Medical Center, 97225, Portland, Oregon, USA

    P. C. Fuchs

Authors
  1. A. L. Barry
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  2. M. A. Pfaller
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  3. P. C. Fuchs
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Barry, A.L., Pfaller, M.A. & Fuchs, P.C. Spontaneously occurring staphylococcal mutants resistant to clinically achievable concentrations of ciprofloxacin and temafloxacin. Eur. J. Clin. Microbiol. Infect. Dis. 11, 243–246 (1992). https://doi.org/10.1007/BF02098088

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