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Specific and nonspecific stimulation of resistance in mice against infection with mycobacterium tuberculosis H37Rv

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Abstract

Intravenous vaccination of mice with oil-treated cell walls of BCG orM. tuberculosis, H37Rv protected against aerosol challenge with virulent tubercle bacilli, whereas protoplasm of these strains or cell walls in aqueous suspension failed to elicit resistance.

The aerosol challenge system has been shown to be the only test system for resistance against tuberculosis with a remarkable specificity, since cell walls of unrelated species likeS. typhimurium orL. monocytogenes were non-protective in this test, in contrast to the conventional “massive intravenous challenge test” where specific and non-specific factors can become effective.

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References

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Author notes

  1. W. Brehmer

    Present address: Robert-Koch-Institut, Berlin, Germany

Authors and Affiliations

  1. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, 59840, Hamilton, Montana

    E. Ribi, W. Brehmer, K. C. Milner & W. C. Wicht

Authors
  1. E. Ribi
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  2. W. Brehmer
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  3. K. C. Milner
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  4. W. C. Wicht
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Ribi, E., Brehmer, W., Milner, K.C. et al. Specific and nonspecific stimulation of resistance in mice against infection with mycobacterium tuberculosis H37Rv. Pneumologie 142, 264–273 (1970). https://doi.org/10.1007/BF02095224

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