Skip to main content
SpringerLink
Log in

The role of unilateral vagotomy on reflex bronchoconstriction

  • Published:
Pneumonologie Aims and scope Submit manuscript

Abstract

Unilateral application of histamine in one segmental bronchus potentiated the airway resistance increase caused by ACH challenge of the bronchial tree. Unilateral or contralateral blockade of the N. vagus reduces the severity of the reaction by about 70% of the values before the blockade.

The arterial blood gases were not influenced by the unilateral blockade of the N. vagus. The decrease of the arterial oxygen pressure following the ACH induced bronchoconstriction was not changed by the unilateral vagotomy.

The breathing patterns change by unilateral vagus blockade: Tidal volume increases by about 50% and the breathing rate decreases by about 30%. The heart rates were remained unchanged.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aviado, D. M., M. Samenek, L. E. Folle: Cardio pulmonary effects of tobacco and related substances: I. “Release of histamine during inhalation of cigarette smoke and anoxemie in the heart lung and intact dog preparation”. Arch. Environm. Hlth.12, 705 (1966)

    Google Scholar 

  2. Barer, G. R., I. R. McCurrie: Pulmonary vasomotor responses in the cat; the effects and interrelationships of drugs, hypoxia and hypercapnia". Quart. J. Expt. Physiol.54, 156 (1969)

    Google Scholar 

  3. Blümcke, S.: Morphologische Grundlagen der Lungeninnervation. Beitr. Klin. Tuberk.138, 229 (1968)

    Google Scholar 

  4. Blümcke, S.: Das negative Nervensystem der Lunge. Med. Welt21, 173 (1970)

    Google Scholar 

  5. DeKock, M. A., J. A. Nadel, S. Zwi, H. J. H. Colebatch, C. R. Olsen: New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea. J. Appl. Physiol.21, 185 (1966)

    PubMed  Google Scholar 

  6. Gold, W. M., G. F. Kessler, D. Y. C. Yo: Role of vagus never in experimental asthma in allergic dogs. J. Appl. Physiol.33, 719 (1972)

    PubMed  Google Scholar 

  7. Hange, A.: Role of histamine in hypoxic pulmonary hypertension in the rats. I. Blockade or potentation of endogenous amines, Kinins and ATP. Circulat. Res.22, 371 (1968)

    PubMed  Google Scholar 

  8. Hayed, v. H.: Die Menschenlunge. p. 338. Berlin-Heidelberg-New York: Springer 1970

    Google Scholar 

  9. Islam, M. S., B. Rasche, E. Vastag, W. T. Ulmer: Empfindlichkeitssteigerung der Bronchialmuskulatur durch proteolytische Fermente im Sputum. Pneumonologie146, 232 (1971)

    PubMed  Google Scholar 

  10. Islam, M. S., W. T. Ulmer: Der Wirkungsmechanismus von Serotonin (5-Hydroxytryptamine) und Histamin bei der Atemwegsobstruktion. Respiration30, 260 (1973)

    PubMed  Google Scholar 

  11. Islam, M. S., K. Lanser, W. T. Ulmer: Einfluß vagaler Reflexe auf Störungen des Belüftungs- und Durchblutungsverhältnisses der Lunge. S. 41. In: Bericht Silikoseforschungsinstitut der Bergbau-Berufsgenossenschaft, 1973

  12. Islam, M. S., W. T. Ulmer: Prostaglandin F2alpha als Bronchokonstriktor. Respiration31, 331 (1974)

    Google Scholar 

  13. Islam, M. S., W. T. Ulmer, W. Kniefeld: Lungenfunktion bei Spannungsverlust der Lunge. Pneumonologie151, 73 (1974)

    PubMed  Google Scholar 

  14. Islam, M. S., W. T. Ulmer: Lokale Überempfindlichkeit sensorischer Rezeptoren als Ursache reflektorischer Atemwegsobstruktion. Respiration32, 445 (1975)

    PubMed  Google Scholar 

  15. Lanser, K., M. S. Islam, W. T. Ulmer: Untersuchungen zur Kontrolle der Ventilationsdurchblutungsregulation der Lunge. Verh. dtsch. Ges. inn. Med.80, 894 (1974)

    PubMed  Google Scholar 

  16. Nolte, D.: Neue Erkenntnisse über Pathophysiologie und Therapie der Bronchokonstriktion. Fortschr. Med.92, 923 (1974)

    PubMed  Google Scholar 

  17. Paintal, A. S.: Impulses in vagus afferent fibres from specific pulmonary deflation receptors. The responses of these receptors to phenyldiguanide potato starch 5-Hydroxytryptamine and nicotine and their role in respiratory and cardiovascular reflexes. Quart. J. Expt. Physiol.40, 89 (1955)

    Google Scholar 

  18. Ulmer, W. T., M. S. Islam, I. Bakran, jr.: Untersuchungen zur Ursache der Atemwegsobstruktion und des überempfindlichen Bronchialystems. Dtsch. med. Wschr.96, 1759 (1971)

    PubMed  Google Scholar 

  19. Ulmer, W. T., M. S. Islam: Die Acetylcholinempfindlichkeit des Bronchialbaumes. Respiration31, 137 (1974)

    PubMed  Google Scholar 

  20. Widdicombe, I. G.: Respiratory reflexes from the trachea and bronchi of the cat. J. Physiol. (London)123, 55 (1954)

    PubMed  Google Scholar 

  21. Widdicombe, I. G.: The activity of pulmonary oedema, atelectasis and breathing against resistance. J. Physiol. (London)159, 436 (1961)

    PubMed  Google Scholar 

  22. Zimmermann, I., M. S. Islam, K. Lanser, W. T. Ulmer: Antigen induced airway obstruction and the influence of vagus blockade. Respiration (i. Druck)

Download references

Author information

Authors and Affiliations

  1. Institut für Lungenfunktionsforschung Bochum in Verbindung mit der Westfälischen Wilhelms-Universität Münster, Germany

    M. S. Islam, I. Zimmermann & W. T. Ulmer

Authors
  1. M. S. Islam
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Zimmermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. T. Ulmer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Islam, M.S., Zimmermann, I. & Ulmer, W.T. The role of unilateral vagotomy on reflex bronchoconstriction. Pneumonologie 152, 281–289 (1975). https://doi.org/10.1007/BF02094942

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02094942

Key words

Search

Navigation