Skip to main content
Log in

Primary pulmonary histiocytosis X immunological analysis in two cases

  • Published:
Pneumonologie Aims and scope Submit manuscript

Abstract

Several immunological markers were studied in two patients with primary pulmonary histiocytosis X diagnosed by open-lung biopsy. The population of T- and B-lymphocytes from peripheral blood and the response of peripheral lymphocytes to phytohemagglutinin were within the normal ranges in two patients. The concentrations of serum IgG, IgA, and IgM in two patients were normal. However, Patient 1 showed a decreased serum IgE level and Patient 2 showed a lower border-line level of serum IgE as well. The selective low serum IgE level was the only immunological abnormality seen in primary pulmonary histiocytosis X.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Adler, W. H., Takiguchi, T., Marsh, B., Smith, R. T.: Cellular recognition by mouse lymphocytes in vitro: 1. Definition of a new technique and results of stimulation by phytohemagglutinin and specific antigens. J. Exp. Med. 131, 1049–1078 (1970)

    PubMed  Google Scholar 

  2. Cline, M. J., Golde, D. W.: A review and reevaluation of the histiocytic disorders. Amer. J. Med.55, 49–60 (1973)

    PubMed  Google Scholar 

  3. Fahey, J. L., McKelvey, E. M.: Quantitative determinations of serum immunoglobulins in antibody-agar plates. J. Immunol.94, 84–90 (1965)

    PubMed  Google Scholar 

  4. Farinacci, C. J., Jefferey, H. C., Lackey, R. W.: Eosinophilic granuloma of lung: Report of two cases. U.S. Armed Forces Med. J.2, 1085–1093 (1951)

    PubMed  Google Scholar 

  5. Hiramatsu, S.: Serum immunoglobulin levels of apparently healthy Japanese determined by single radial immunodiffusion method. Igaku no Ayumi77, 157–162 (1971) (in Japanese)

    Google Scholar 

  6. Iwai, K., Maruyama, M., Taziri, S.: Report of a case of pulmonary eosinophilic granuloma. Nihon Rinsho15, 2015–2019 (1957) (in Japanese)

    Google Scholar 

  7. Jondal, M., Holm, G., Wigzell, H.: Surface markers on human T and B lymphocytes: 1. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J. Exp. Med.136, 207–215 (1972)

    PubMed  Google Scholar 

  8. Lamerz, R., Fateh-Moghadam, A.: Immunoglobulin E: Biochemische, immunologische Eigenschaften und klinische Bedeutung. Klin. Wschr.52, 1–17 (1974)

    PubMed  Google Scholar 

  9. Leikin, S., Puruganan, G., Frankel, A., Steerman, R., Chandra, R.: Immunologic parameters in histiocytosis X. Cancer32, 796–802 (1973)

    PubMed  Google Scholar 

  10. Lewis, J. G.: Eosinophilic granuloma and its variants with special reference to lung involvement. Quat. J. Med.33, 337–359 (1964)

    Google Scholar 

  11. Lichitenstein, L.: Histiocytosis X: Integration of eosinophilic granuloma of bone, "Letterer-Siwe disease" and "Schüller-Christian disease" as related manifestations of a single nosologic entity. A. M. A. Arch. Path.56, 84–102 (1953)

    PubMed  Google Scholar 

  12. Lieberman, P. H., Jones, C. R., Dargeon, H. W. K., Bagg, C. F.: A reappraisal of eosinophilic granuloma of bone, Hand-Schüller-Christian syndrome, and Letterer-Siwe syndrome. Medicine48, 375–400 (1969)

    PubMed  Google Scholar 

  13. Turiaf, J., Basset, F.: Pulmonale Histiozytose "X": Nosologische und ätiologische Aspekte. Münch. Med. Wschr.109, 805–815 (1967)

    Google Scholar 

  14. Yagura, T., Shimizu, M., Yamamura, Y., Tachibana, T.: The serum IgE level and reaginic type skin reactions in sarcoidosis. Reported at VIII International Congress of Allergology in Tokyo, 1973. Excerpta Medica, International Congress Series No.300, 16 (1973)

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hiwada, K., Konishiike, J., Sera, Y. et al. Primary pulmonary histiocytosis X immunological analysis in two cases. Pneumonologie 152, 259–266 (1975). https://doi.org/10.1007/BF02094939

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02094939

Keywords

Navigation