Digestive Diseases and Sciences

, Volume 41, Issue 2, pp 377–386 | Cite as

Carcinoma in gastric hyperplastic polyps

A phenotypic study
  • Walter-Leopoldo Zea-Iriarte
  • Ichiro Sekine
  • Minoru Itsuno
  • Kazuya Makiyama
  • Shinji Naito
  • Toshiyuki Nakayama
  • Juan-Eiki Nishisawa-Takano
  • Takanori Hattori
Gastrointestinal Oncology


One-hundred twelve hyperplastic polyps were analyzed. The aim was to study their malignant transformation. Among them, four hyperplastic polyps harbored adenocarcinoma; two were from our own institution (1.8%). The majority were pedunculated and located in the antrum with an average of 14.5 mm in diameter. The four polyps bore well-differentiated adenocarcinoma. Dysplasia and intestinal metaplasia were detected in two and three polyps, respectively. The cancer and dysplastic foci shared the same type of neutral and acid mucosubstances. p53 oncoprotein was positive in three cancer foci and in the dysplastic areas, and nucleolar organizer region counts were higher in the cancer foci. In conclusion, hyperplastic polyps have malignant potential. Such possibility increases in polyps larger than 14.5 mm. In our cases, the carcinoma foci may have arisen from dysplastic areas. Once the neoplastic changes occur, the cancer cells proliferate and behave as other adenocarcinomas of the stomach.

Key words

hyperplastic polyps malignant changes cancer foci dysplasia adenocarcinoma intestinal metaplasia 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Walter-Leopoldo Zea-Iriarte
    • 1
    • 2
  • Ichiro Sekine
    • 1
    • 2
  • Minoru Itsuno
    • 1
    • 2
  • Kazuya Makiyama
    • 1
    • 2
  • Shinji Naito
    • 1
    • 2
  • Toshiyuki Nakayama
    • 1
    • 2
  • Juan-Eiki Nishisawa-Takano
    • 1
    • 2
  • Takanori Hattori
    • 1
    • 2
  1. 1.From the Second Department of Internal Medicine; Department of Pathology, Atomic Disease Institute; and the First Department of SurgeryNagasaki University School of MedicineNagasakiJapan
  2. 2.the Department of PathologyShiga University School of Medical ScienceSeta, OhtsuJapan

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