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Herzveränderungen bei akutem intrakraniellen Druckanstieg

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Summary

Myocardial lesions occuring in diseases with acute increase of intracranial pressure were investigated. Morphologic alterations in heart muscle in spite of different lengh of surviving and various causes of the death were of similar type. In every case subendocardial haemorrhage could be observed on the septal surface and on the papillary muscle of the left ventricle. Focal intracellular edema, myocytolysis were revealed in 76 %, focal necrosis of hypercontractic type developed in 52 % of the cases. Cellular infiltration occurred around the alternations observed in 3 cases.

It is concluded, that damage to the heart muscle is not caused directly by the increased intracranial pressure or catecholamine mobilisation, but seems to be the consequence of the acute myocardial hypoxia.

Zusammenfassung

Bei Todesfällen wegen akuter intrakranieller Drucksteigerung wurden die eingetretenen Myokardveränderungen untersucht. In 76 % der Fälle waren degenerative, in 57 % nekrotische Veränderungen nachweisbar. Zwischen Manifestation, Lebensalter sowie anderen Organsymptomen bestand kein Zusammenhang. Auf Grund der erhobenen Befunde kommt primär ein Sauerstoffmangel als ursächlicher Faktor in Frage, eine Tonusdifferenz des vegetativen Nervensystems sollte nur als modifizierender Faktor angenommen werden.

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Literatur

  1. Anichkow, S. V., Wedeneewa, Z. I.: Irritation of the sympathetic nerve as a cause of myocardial lesions. Acta Physiol.19, 17–18 (1961)

    Google Scholar 

  2. Bersch, W., Bühler, W., Kreinsen, R.: Ein pathomorphologischer Beitrag zur Kenntnis der sogenannten Epinephrin-Myocarditis. Virchow's Arch. Abt. A.360, 45 (1973)

    Google Scholar 

  3. Connor, R.C.R.: Heart damage associated with intracranial lesions. Brit. med. J.3, 29–31 (1968)

    PubMed  Google Scholar 

  4. Connor, R.C.R.: Focal myocytolysis and fuchsinophilic degeneration of the myocardium of patients dying with various brain lesions. Ann. N.Y. Acad. Sci.156, 261–270 (1969)

    PubMed  Google Scholar 

  5. Dömötör, L.: Zur Pathomorphologie der Herzveränderungen bei Patienten mit Pheocromocytom. Zbl. allg. Path. path. Anat.116, 121–127 (1972)

    Google Scholar 

  6. Cropp, G.J., Manning, G. W.: Electrocardiographic changes simulating myocardial ischemia and interaction associated with spontaneous intracranial haemorrhage. Circulation22, 39–49 (1960)

    PubMed  Google Scholar 

  7. Eichbaum, F.W., Pereira, B.: Effect of cranial trauma on the electrocardiogramm. Experiments in Guinea pigs. Cardiologia (Basel)44, 46–67 (1964)

    Google Scholar 

  8. Eppinger, H., Tothberger, J.: Über die Folgen der Durchschneidung der Tawaraschen Schenkel des Reizleitungssystems. Z. klin. Med.70, 1–20 (1910)

    Google Scholar 

  9. Fassbender, H. G.: Vagustonus und subendocardiale Blutungen. Verh. dtsch. Ges. Path.39, 373–375 (1956)

    Google Scholar 

  10. Feulz, V., Gromsen, J.: Electrocardiographic patterns in patients with cerebrovascular accidents. Circulation25, 22–29 (1962)

    PubMed  Google Scholar 

  11. Fiala, E., Abafalvi, A., Fényes, Gy.: Einen Myokardinfarkt nachahmendes EKG-Bild bei subarachnoidaler Blutung. Orv. Hetil.108, 1507–1509 (1967) (In ungarisch)

    Google Scholar 

  12. Fleischer, M. S., Loeb, L.: Experimental myocarditis. Arch. Int. Med.3, 78–91 (1909)

    Google Scholar 

  13. Hansson, L., Larsson, O.: The incidence of ECG abnormalities in acute cerebrovascular accidents. Acta med. scand.195, 45–47 (1974)

    PubMed  Google Scholar 

  14. Heincirh, D., Müller, W.: Fokale Myokardnekrosen bei akuter intrakranieller Drucksteigerung. Zbl. allg. Path. path. Anat.118, 554 (1974)

    Google Scholar 

  15. Ilinski, B. V., Astrakhanseva, S. P.: Character and genesis of electrocardiographic changes in cerebral insults. Cor et Vasa9, 251–268 (1968)

    Google Scholar 

  16. Jacob, W. A., van Bogaert, A., de Groodt-Lasseel, M. H. A.: Myocardial ultrastructure and haemodynamic reactions during experimental subarachnoid haemorrhage. J. Molec. Cell. Cardiol.4, 287–298 (1972)

    Google Scholar 

  17. Jennings, R. B., Sommers, H. M., Herdson, P. B., Kaltenbach, J. P. Ischemic injury of myocardium. Ann. N. Y. Acad. Sci.156. 61–69 (1969)

    PubMed  Google Scholar 

  18. Kaye, M. P., McDonald, R. H., Randan, W. C.: Systolic hypertension and subendocardial haemorrhages produced by electrical stimulation of the stellate ganglion. Circulat. Res.9, 1164–1170 (1961)

    PubMed  Google Scholar 

  19. Klouda, M. A., Bryngolfsson, G.: Cardiotoxic effects of electrical stimulation of the stellate ganglia. Ann. N. Y. Acad. Sci.156, 271–280 (1969)

    PubMed  Google Scholar 

  20. Levine, H. D.: Non-specificity of the electrocardiogramm associated with coronary heart disease. Amer. J. Med.15, 344 (1953)

    PubMed  Google Scholar 

  21. Lubich, T., di Paolo, E., Boni, F.: La sindrome cerebrocardiaca. Fol. cardiol.15, 629–660 (1956)

    Google Scholar 

  22. Ludwig, G.: Capillary pattern of the myocardium. Meth. Achievm. Path.5, 228–251 (1971)

    Google Scholar 

  23. Mamming, G. W., Hall, G. E., Banting, F. G.: Vagus stimulation and the production of myocardial damage. Canad. Med. Ass. J.37, 314–318 (1937)

    Google Scholar 

  24. Marin, A. M., Hackel, D. B., Kurtz, S. M.: The ultrastucture of zonal lesions of the myocardium in haemorrhagic shock. Amer. J. Pathol.44, 127–140 (1964)

    Google Scholar 

  25. Melville, K. I., Blum, B., Shister, H. E., Silver, M. D.: Cardiac ischemic changes and arrhythmias induced by hypothalamic stimulation. Amer. J. Cardiol.12, 781–791 (1963)

    PubMed  Google Scholar 

  26. Melville, K. I., Gorvey, H. L., Shister, H. E., Knaack, J.: Central nervous systems stimulation and cardiac ischemic changes im monkeys. Ann. N. Y. Acad. Sci.156, 241–260 (1969)

    PubMed  Google Scholar 

  27. Méhes, G., Papp, G., Rajkovits, K.: Effect of adrenergic and receptor blocking drugs on the myocardial lesion induced by sympathomimetic amines. Acta Physiol. Acad. Sci. Hung.32, 175–184 (1967)

    PubMed  Google Scholar 

  28. Ökrös, S.: Veränderungen der Herzmuskelfasern bei Thromboembolie. Beitr. gerichtl. Med.22, 253–258 (1964)

    Google Scholar 

  29. Palossy, B., Szabolcs, I.: Wirkung cerebrovasculärer Insulte auf das elektrische Herzgeschehen. Orv. Hetil.116, 1148–1152 (1975) (in ungarisch)

    PubMed  Google Scholar 

  30. Ratliff, N. B., Hackel, D. B., Mikat, E.: Myocardial carbohydrate metabolism and lesions in haemorrhagic shock. Arch. Pathol.88, 470–475 (1969)

    PubMed  Google Scholar 

  31. Ratliff, N. B., Kopelman, R. I., Goldner, R. D.: Formation of myocardial zonal lesions. Amer. J. Pathol.79, 321–334 (1975)

    Google Scholar 

  32. Reichenbach, D., Grennhoot, J. H., Benditt, E. P.: Cardiac necrosis produced by endogenous catecholamines. Fed. Proc.28, 748 (1969)

    Google Scholar 

  33. Rona, G., Chappel, C. I., Balázs, T., Gaudry, R.: An infarct like myocardial lesion and other toxic manifestation produced by isoproterenol. Arch. Pathol.67, 443–455 (1959)

    Google Scholar 

  34. Varga, T., Szinay, Gy., Soos, J., Köves, I.: Heat muscol changes after open heart surgery. Acta Morph. Acad. Sci., Hung.21, 213–224 (1973)

    Google Scholar 

  35. Wahi, P. L.: Electrocardiographie changes associated with cerebrovascular accidents. Lancet 1965/I, 660

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Authors and Affiliations

  1. Institut für Medizinische Sachverständige, Postfach 31, H-1363, Budapest, Ungarn

    Tibor Varga & Árpád Szabó

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  1. Tibor Varga
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  2. Árpád Szabó
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Varga, T., Szabó, Á. Herzveränderungen bei akutem intrakraniellen Druckanstieg. Z Rechtsmed 80, 311–318 (1978). https://doi.org/10.1007/BF02092329

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