Skip to main content
Log in

Lethal orphenadrine intoxication: Report of a case

  • Kasuistik / Casuistry
  • Published:
Zeitschrift für Rechtsmedizin Aims and scope Submit manuscript

Summary

A case of lethal orphenadrine intoxication is reported. Included are the anatomical and toxicological findings. Most conspicuous histologically was the centrilobular necrosis of the liver.

Zusammenfassung

Ein Fall von Orphenadrin-Vergiftung wird beschrieben. Über anatomischen und toxikologischen Untersuchungsbefunde wird berichtet. Mikroskopisch fällt in erster Linie die Lebernekrose auf.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Blomquist, M., Bonnichsen, R., Schubert, B.: Lethal orphenadrine intoxications: a report of five cases. Z. Rechtsmed.68, 111 (1971)

    PubMed  Google Scholar 

  2. Boidi, C., Risso, A.M., Robert, G.: Su di un caso di intossicazione acuta da orfenadrina. Min. Psichiat. Psicol.16, 116 (1975)

    Google Scholar 

  3. Bösche, J., Mallach, H.J.: Über anatomische und chemisch-toxikologische Befunde bei einer tödlichen Vergiftung durch Orphenadrin. Arch. Toxikol.25, 76 (1969)

    PubMed  Google Scholar 

  4. Bozza-Marrubini, M., Frigerio, A., Ghezzi, R., Parelli, L., Restelli, L., Selenati, A.: Two cases of severe orphenadrine poisoning with atypical features. Acta Pharmacol. Toxicol.41, Suppl II, 137 (1977)

    Google Scholar 

  5. Bruno Monti, G., Circulli, A., Andreucci, G., Malizia, E.: Su un caso di intossicazione grave da orfenadrina e reserpina. Riv. Tossicol. Sper. Clin.8, 47 (1978)

    Google Scholar 

  6. Clarke, E.G.C.: Isolation and identification of drugs. London: The Pharmaceutical Press 1969

    Google Scholar 

  7. Curry, A.A.: Twenty-one uncommon cases of poisoning. Brit. Med. J.I, 687 (1962)

    Google Scholar 

  8. Curry, A.S., Fox R.: Int. Ass. Forens. Toxicol.I, no. 4 (1964)

  9. Obersteg, I., Im Bäumler, J.: Ueber Suizide mit Psychophaimaka. Münch. Med. Wschr.106, 969 (1964)

    Google Scholar 

  10. Jackson, J.V.: personal communication to Clarke (ref. 6).

  11. Kimber, K.: Fatal orphenadrine (Disipal) case. Int. Ass. Forens. Toxicol.2, no. 3 (1965) (1965)

  12. Martindale's Extra Pharmacopoeia, 26th ed. London: The Pharmaceutical Press 1972

  13. Robinson, A.E., Holder, A.T., McDowall, R.D., Powell, R., Sattar, H.: Forensic toxicology of some orphenadrine-related deaths. Forens. Sci.9, 53 (1977)

    Google Scholar 

  14. Rossi, G., Giusti, G.V.: Lethal intoxication with Phasein®. Zacchia49, 469 (1974)

    Google Scholar 

  15. Sangster, B., Heijst, A.N.P. van, Zimmermann, A.N.E., Vries, H.W. de: Intoxication by orphenadrine HCl: mechanism and therapy. Acta Pharmacol. Toxicol.41, Suppl. II, 129 (1977)

    Google Scholar 

  16. Stoddard, J.C., Parkin, J.M., Wynne, N.A.: Orphenadrine poisoning: a case report. Brit. J. Anaesth.40, 789 (1978)

    Google Scholar 

  17. Winek, C.L.: Injury by chemical agents. In: Forensic Medicine, Tedeschi, C.G., Eckert, W.G., Tedeschi, L.G. (eds.), pp. 1568–1578 Philadelphia, London, Toronto: W.B. Saunders, Co.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

De Mercurio, D., Chiarotti, M. & Giusti, G.V. Lethal orphenadrine intoxication: Report of a case. Z Rechtsmed 82, 349–353 (1979). https://doi.org/10.1007/BF02092047

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02092047

Key words

Schlüsselwörter

Navigation