Summary
An investigation was carried out on the effect of the intake of diazepam and alcohol on simple performance tests. The combined administration of diazepam and alcohol led to an increase of the plasma diazepam concentration as compared to that obtained after diazepam without alcohol. Furthermore, after combined intake of diazepam and alcohol a decrease of performance was observed, that was significantly higher, than the effects obtained after either alcohol or diazepam alone. This impairment was especially noticeable during the first hour of the experiment, i.e. until the plateau of the diazepam plasma concentration was reached, while afterwards a correlation between diazepam plasma concentration and impairment of performance could not be established. The relevance of these findings for the interpretation of diazepam plasma concentrations in relation to the impairment of performance are discussed.
Zusammenfassung
In einer an 65 Versuchspersonen durchgeführten Untersuchung wurde die Auswirkung der kombinierten Einnahme von Alkohol und Diazepam auf die Leistungsfähigkeit untersucht. Es zeigte sich, daß die Plasmaspiegel bei gleichzeitiger Einnahme von Alkohol und Diazepam höher waren als bei alleiniger Gabe von Diazepam. In gleicher Weise ergaben sich bei der Kombination beider Mittel höhere Leistungsbeeinträchtigungen als bei getrennter Einnahme von Alkohol und Diazepam. Die Wirkung war in der ersten Stunde nach der Medikation besonders deutlich und ging mit zunehmender Zeit zurück. Eine besondere Leistungsbeeinträchtigung besteht demnach in der Anflutungs- und früheren Plateauphase, während später trotz eines noch relativ hohen Plasmaspiegels weniger starke Leistungsminderungen nachweisbar sind. Die Bedeutung der Beziehung zwischen Plasmaspiegel und Leistungsbeeinträchtigung wird diskutiert.
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Lutze, J., Gelbke, HP. & Schmidt, G. Zur Leistungsbeeinträchtigung durch Alkohol und Diazepam. Z Rechtsmed 82, 327–336 (1979). https://doi.org/10.1007/BF02092045
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DOI: https://doi.org/10.1007/BF02092045