Digestive Diseases and Sciences

, Volume 41, Issue 5, pp 884–893 | Cite as

Jejunoileal transplantation

Effects on characteristics of canine jejunal motor activityin Vivo
  • Kevin E. Behrns
  • Michael G. Sarr
  • Russell B. Hanson
  • Alan R. Zinsmeister
Intestinal Disorders, Inflammatory Bowel Disease, Immunology, And Microbiology

Abstract

This study was designed to determine if extrinsic innervation and intrinsic neural continuity with the duodenum (neuroenteric physiologic pathways disrupted during intestinal transplantation) modulate the characteristics of interdigestive motor activity in the canine small bowel. Five dogs served as neurally intact controls (group 1) and 10 dogs (group 2) underwent a model of jejunal autotransplantation involvingin situ neural isolation of the jejunoileum. Fasting duodenal and jejunal motor activity was recorded on-line to a microcomputer using closely spaced duodenal and jejunal manometry catheters. Characteristics of global motor patterns, the migrating motor complex (MMC), and local motor patterns, including individual contractions and grouped clustered contractions, were determined. Neural isolation of the jejunoileum disrupted coordination of duodenal and jejunal phase III activity, increased the variability of cycling of the MMC, decreased the period of the jejunal MMC, and increased motility indices in the neurally isolated jejunum. In contrast, single pressure waves and clustered contractions in the neurally isolated jejunum were not altered significantly in incidence or direction, distance, or velocity of spread.In situ neural isolation of the jejunoileum leads to temporal dissociation of the MMC between the transplanted segment (jejunum) and the duodenum but does not appear to alter markedly the characteristics of local contractile activity as measured by individual or grouped contractions. The occurrence of interdigestive jejunal motor patterns and the local organization of individual and grouped small intestinal contractions are not controlled by extrinsic innervation or intrinsic neural continuity with the duodenum.

Key words

small intestinal motility motor patterns migrating motor complex in situ neural isolation of the small intestine single pressure waves contractions clustered contractions 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Kevin E. Behrns
    • 1
    • 2
  • Michael G. Sarr
    • 1
    • 2
  • Russell B. Hanson
    • 1
    • 2
  • Alan R. Zinsmeister
    • 1
    • 2
  1. 1.From the Department of SurgeryGastroenterologic Research UnitUSA
  2. 2.the Department of Health Science ResearchMayo Clinic and Mayo FoundationRochester

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