Digestive Diseases and Sciences

, Volume 41, Issue 5, pp 884–893 | Cite as

Jejunoileal transplantation

Effects on characteristics of canine jejunal motor activityin Vivo
  • Kevin E. Behrns
  • Michael G. Sarr
  • Russell B. Hanson
  • Alan R. Zinsmeister
Intestinal Disorders, Inflammatory Bowel Disease, Immunology, And Microbiology


This study was designed to determine if extrinsic innervation and intrinsic neural continuity with the duodenum (neuroenteric physiologic pathways disrupted during intestinal transplantation) modulate the characteristics of interdigestive motor activity in the canine small bowel. Five dogs served as neurally intact controls (group 1) and 10 dogs (group 2) underwent a model of jejunal autotransplantation involvingin situ neural isolation of the jejunoileum. Fasting duodenal and jejunal motor activity was recorded on-line to a microcomputer using closely spaced duodenal and jejunal manometry catheters. Characteristics of global motor patterns, the migrating motor complex (MMC), and local motor patterns, including individual contractions and grouped clustered contractions, were determined. Neural isolation of the jejunoileum disrupted coordination of duodenal and jejunal phase III activity, increased the variability of cycling of the MMC, decreased the period of the jejunal MMC, and increased motility indices in the neurally isolated jejunum. In contrast, single pressure waves and clustered contractions in the neurally isolated jejunum were not altered significantly in incidence or direction, distance, or velocity of spread.In situ neural isolation of the jejunoileum leads to temporal dissociation of the MMC between the transplanted segment (jejunum) and the duodenum but does not appear to alter markedly the characteristics of local contractile activity as measured by individual or grouped contractions. The occurrence of interdigestive jejunal motor patterns and the local organization of individual and grouped small intestinal contractions are not controlled by extrinsic innervation or intrinsic neural continuity with the duodenum.

Key words

small intestinal motility motor patterns migrating motor complex in situ neural isolation of the small intestine single pressure waves contractions clustered contractions 


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  1. 1.
    Sarna S: Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 89:894–913, 1985Google Scholar
  2. 2.
    Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763, 1969Google Scholar
  3. 3.
    Schemann M, Ehrlein H-J: Effects of neurohormonal agents on jejunal contraction spread and transit in the fed dog. Gastroenterology 90:1950–1955, 1986Google Scholar
  4. 4.
    Schemann M, Siegle M-L, Sahyoun H, Ehrlein H-J: Computer analysis of intestinal motility: Effects of cholecystokinin and neurotensin on jejunal contraction patterns. Z Gastroenterol 24:262–268, 1986Google Scholar
  5. 5.
    Todo S, Tzakis A, Reyes J, Abu-Elmagd K, Furukawa H, Nour B, Casavilla A, Nakamura K, Fung J, Demetris J, Starzl T: Small intestinal transplantation in humans with or without the colon. Transplantation 57:840–846, 1994Google Scholar
  6. 6.
    Sarr MG, Duenes JA, Tanaka M: A model of jejunoilealin vivo neural isolation of the entire jejunoileum: Transplantation and the effects on intestinal motility. J Surg Res 47:266–272, 1989Google Scholar
  7. 7.
    Arnold JH, Alevizatos CA, Cox SE, Richards WO: Propagation of small bowel migrating motor complex activity fronts varies with anastomosis type. J Surg Res 51:506–511, 1991Google Scholar
  8. 8.
    Sarna S, Condon RE, Cowles V: Enteric mechanisms of initiation of migrating myoelectric complexes in dogs. Gastroenterology 84:814–822, 1983Google Scholar
  9. 9.
    Sarr MG, Duenes JA, Walters AM: Jejunal and ileal absorptive function after a model of canine jejunoileal autotransplantation. J Surg Res 51:233–239, 1991Google Scholar
  10. 10.
    Miedema BW, Sarr MG, Hanson RB, Kelly KA: Electric and motor patterns associated with canine jejunal transit of liquids and solids. Am J Physiol 262:G962-G970, 1992Google Scholar
  11. 11.
    Behrns KE, Sarr MG, Hanson RB, Benson JT, Zinsmeister AR: Effect of enteric non-nutrient infusions on motor patterns in neurally intact and neurally isolated canine jejunum. J Surg Res (in press)Google Scholar
  12. 12.
    Ehrlein H-J, Schemann M, Siegle M-L: Motor patterns of small intestine determined by closely spaced extraluminal transducers and videofluoroscopy. Am J Physiol 253:G259-G267, 1987Google Scholar
  13. 13.
    Siegle M-L, Bühner S, Schemann M, Schmid H-R, Ehrlein H-J: Propagation velocities and frequencies of contractions along canine small intestine. Am J Physiol 258:G738-G744, 1990Google Scholar
  14. 14.
    Dusdieker NS, Summers RW: Longitudinal and circumferential spread of spike bursts in canine jejunumin vivo. Am J Physiol 239:G311-G318, 1980Google Scholar
  15. 15.
    Quigley EMM, Spanta AD, Rose SG, Lof J, Thompson JS: Long-term effects of jejunoileal autotransplantation on myoelectric activity in canine small intestine. Dig Dis Sci 35:1505–1517, 1990Google Scholar
  16. 16.
    Heppell J, Kelly KA, Sarr MG: Neural control of canine small intestinal interdigestive myoelectric complexes. Am J Physiol 244:G95-G100, 1983Google Scholar
  17. 17.
    Aeberhard PF, Magnenat LD, Zimmerman WA: Nervous control of migratory myoelectric complex of the small bowel. Am J Physiol 238:G102-G108, 1980Google Scholar
  18. 18.
    Morrison P, Miedema BW, Kohler L, Kelly KA: Electrical dysrhythmias in Roux jejuna limb: Cause and treatment. Am J Surg 160:252–256, 1990Google Scholar
  19. 19.
    Miedema BW, Kelly KA: The Roux stasis syndrome. Treatment by pacing and prevention by use of an “uncut” Roux limb. Arch Surg 127:295–300, 1992Google Scholar
  20. 20.
    Milton GW, Smith AWM: The pacemaking area of the duodenum. J Physiol 132:100, 1956Google Scholar
  21. 21.
    Kruis W, Azpiroz F, Phillips SF: Contractile patterns and transit of fluid in canine terminal ileum. Am J Physiol 249:G264-G270, 1985Google Scholar
  22. 22.
    Schemann M, Ehrlein H-J: Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology 90:991–1000, 1986Google Scholar
  23. 23.
    Frantzides CT, Sarna SK, Matsumoto T, Lang IM, Condon RE: An intrinsic neural pathway for long intestino-intestinal inhibitory reflexes. Gastroenterology 92:694–603, 1987Google Scholar
  24. 24.
    Marlett JA, Code CF: Effects of celiac and superior mesenteric ganglionectomy on interdigestive myoelectric complex in dogs. Am J Physiol 237:E432-E436, 1979Google Scholar
  25. 25.
    Sarr MG, Kelly KA, Gladen HE: Electrical control of canine jejunal propulsion. Am J Physiol 240:G355-G360, 1981Google Scholar
  26. 26.
    Tanner WA, O'Leary JF, Byrne PJ, Hennesssy TPJ: The effect of reversed jejunal segments on the myoelectric activity of the small bowel. Br J Surg 65:567–571, 1978Google Scholar
  27. 27.
    Bjornsson E, Abrahamsson H: MMC-related duodenojejunal antegrade and retrograde peristalsis in humans. Neurogastroenterol Motil 6:303–309, 1994Google Scholar
  28. 28.
    Cannon WB: The passage of different food-stuffs from the stomach and through the small intestine. Am J Physiol 12:387–418, 1905Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Kevin E. Behrns
    • 1
    • 2
  • Michael G. Sarr
    • 1
    • 2
  • Russell B. Hanson
    • 1
    • 2
  • Alan R. Zinsmeister
    • 1
    • 2
  1. 1.From the Department of SurgeryGastroenterologic Research UnitUSA
  2. 2.the Department of Health Science ResearchMayo Clinic and Mayo FoundationRochester

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