Digestive Diseases and Sciences

, Volume 39, Issue 1, pp 152–156 | Cite as

Interleukin-1 receptor antagonist does not prevent endotoxin-induced inhibition of gastric acid secretion in rats

  • Esteban Saperas
  • Yvette Taché
Original Article


The underlying mechanisms involved in endotoxin-induced inhibition of gastric acid secretion were investigated in conscious rats with pylorus ligation for 2 hr. Intraperitoneal injection of endotoxin (0.1, 1, and 5 µg/rat) inhibited gastric acid output by 31%, 80%, and 84% respectively. Intraperitoneal endotoxin (1 µg/rat) -induced inhibition of gastric acid secretion was not altered by pretreatment with the interleukin-1 receptor antagonist, IL-1RA, indomethacin, naloxone, or capsaicin. Treatments were injected peripherally at doses previously shown to antagonize the antisecretory effect of exogenous interleukin-1β, to inhibit prostaglandin synthesis in the stomach and brain, to block opiate receptors, and to alter functioning of unmyelinated afferent nerve fibers. These results indicate that the antisecretory effect of endotoxin can be expressed by factors other than interleukin-1, prostaglandins, or opioid peptides that do not require the integrity of capsaicin-sensitive afferent pathways.

Key words

endotoxin gastric acid secretion interleukin-1 receptor antagonist indomethacin capsaicin 


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Esteban Saperas
    • 1
    • 2
  • Yvette Taché
    • 1
    • 2
  1. 1.From the CURE/Digestive Disease Center, VA Wadsworth Medical Center, Department of Medicine and Brain Research InstituteUCLALos Angeles
  2. 2.the Digestive System Research UnitHospital Vall d'HebronBarcelonaSpain

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