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Interleukin-1 receptor antagonist does not prevent endotoxin-induced inhibition of gastric acid secretion in rats

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Abstract

The underlying mechanisms involved in endotoxin-induced inhibition of gastric acid secretion were investigated in conscious rats with pylorus ligation for 2 hr. Intraperitoneal injection of endotoxin (0.1, 1, and 5 µg/rat) inhibited gastric acid output by 31%, 80%, and 84% respectively. Intraperitoneal endotoxin (1 µg/rat) -induced inhibition of gastric acid secretion was not altered by pretreatment with the interleukin-1 receptor antagonist, IL-1RA, indomethacin, naloxone, or capsaicin. Treatments were injected peripherally at doses previously shown to antagonize the antisecretory effect of exogenous interleukin-1β, to inhibit prostaglandin synthesis in the stomach and brain, to block opiate receptors, and to alter functioning of unmyelinated afferent nerve fibers. These results indicate that the antisecretory effect of endotoxin can be expressed by factors other than interleukin-1, prostaglandins, or opioid peptides that do not require the integrity of capsaicin-sensitive afferent pathways.

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Authors and Affiliations

  1. From the CURE/Digestive Disease Center, VA Wadsworth Medical Center, Department of Medicine and Brain Research Institute, UCLA, 90073, Los Angeles, California

    Esteban Saperas MD & Yvette Taché PhD

  2. the Digestive System Research Unit, Hospital Vall d'Hebron, Barcelona, Spain

    Esteban Saperas MD & Yvette Taché PhD

Authors
  1. Esteban Saperas MD
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  2. Yvette Taché PhD
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Additional information

Supported by the National Institute of Arthritis Metabolism and Digestive Disease, grant DK-30110, and the Institute of Mental Health, grant MH-00663, a Research Grant from the Psychoneuroimmunology Program at UCLA, and the “Direction General de Investigacion Cientificas Y Técnicas” (DGICYT PM—0124 to Dr. E. Saperas).

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Saperas, E., Taché, Y. Interleukin-1 receptor antagonist does not prevent endotoxin-induced inhibition of gastric acid secretion in rats. Digest Dis Sci 39, 152–156 (1994). https://doi.org/10.1007/BF02090075

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  • DOI: https://doi.org/10.1007/BF02090075

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