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Testicular germ cell tumours

Current problems of histogenesis and classification

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Abstract

Testicular germ cell tumours, owing to their variety in biological behaviour and morphological appearance, claim a place of their own in clinical oncology and tumour research. Much of the histogenesis has remained unexplained, as reflected by the different systems of pathological classification. This report sums up on basis of the literature, the current pathologic views on the question of testicular tumour genesis. Data obtained from immune histochemical examinations, animal experiments, ultrastructure studies, together with clinical observations, suggest that differentiation of the carcinomatous stem cells are apt to produce forms, transitional between seminomatous and non-seminomatous types of tumour. The possibility to set up a uniform, clinically appropriate nomenclature depends on the progress in histogenetic knowledge.

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References

  1. Akhtar, M., Sidiki, Y.: Undifferentiated intratubular germ cell tumor of the testis. Light and electron microscopic study of a unique case.Cancer, 43, 2332 (1979).

    Google Scholar 

  2. Askanazy, M.: Die Teratome nach ihrem Bau, ihrem Verlauf, ihrer Genese und im Vergleich zum experimentellen Teratoid.Verh. Dtsch. Ges. Pathol., 11, 39 (1907).

    Google Scholar 

  3. Bär, W., Hedinger, Ch.: Comparison of histologic types of primary testicular germ cell tumours with their metastases. Consequences for the WHO and the British nomenclatures?Virchows Arch. [Abt. A. Pathol. Anat. and Histol.],370, 41 (1976).

    Google Scholar 

  4. Berthelsen, J. G. Skakkebaek, N. E., Mogensen, P., Sørensen, B. L.: Incidence of carcinoma in situ of germ cells in contralateral testis of men with testicular tumours.Br. Med. J., 2, 363 (1979).

    Google Scholar 

  5. Bosman, F. T., Giard, R. W. M., Nieuwenhuijen Kruseman, A. C., Spaander, P. J.: Human chorionic gonadotrophin and alpha-fetoprotein in testicular germ cell tumours: a retrospective immunohistochemical study.Histopathology, 4, 673 (1980).

    Google Scholar 

  6. Brown, N. J.: Teratomas and yolk-sac tumours.J. Clin. Pathol., 29, 1021 (1976).

    Google Scholar 

  7. Carr, B. I., Gilchrist, K. W., Carbone, P. P.: The variable transformation in metastases from testicular germ cell tumors: the need for selective biopsy.J. Urol., 126, 52 (1981).

    Google Scholar 

  8. Clemmesen, J.: Testis cancer incidence — suggestion of a world pattern.Int. J. Androl., Suppl.4, 111 (1981).

    Google Scholar 

  9. Dixon, F. J., Moore, R. A.: Tumors of the male sex organs. Atlas of Tumor Pathology, Fasc. 31b and 32. Armed Forces Institute of Pathology, Washington 1952.

    Google Scholar 

  10. Einhorn, L. H.: Testicular cancer as a model for a curable neoplasm: the Richard and Hinda Rosenthal award lecture.Cancer Res., 41, 3275 (1981).

    Google Scholar 

  11. Friedman, N. B.: The comparative morphogenesis of extragenital and gonadal teratoid tumors.Cancer, 4, 265 (1951).

    Google Scholar 

  12. Friedman, N. B., Moore, R. A.: Tumors of the testis: a report on 922 cases.Milit. Surgeon, 99, 573 (1946).

    Google Scholar 

  13. Grigor, K. M.: Extra embryonic elements in testicular tumours.Int. J. Androl., 54, 35 (1981).

    Google Scholar 

  14. Hedinger, Ch. E., Hochstetter, A. R., Egloff, B.: Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma.Virchows Arch. [Abt. A. Path. Anat. and Histol.],383, 59 (1979).

    Google Scholar 

  15. Hochstetter, A. R., Hedinger, Ch. E.: The differential diagnosis of testicular germ cell tumors in theory and practice. A critical analysis of two major systems of classification and a review of 389 cases.Virchows Arch. [Pathol. Anat.],396, 247 (1982).

    Google Scholar 

  16. Hong, W. K., Wittes, R. E., Hajdu, S. T., Cvitkovic, E., Whitmore, W. F., Golbey, R. B.: The evolution of mature teratoma from malignant testicular tumors.Cancer, 40, 2987 (1977).

    Google Scholar 

  17. Jacobsen, G. K., Henriksen, O. B., V. der Maase, H.: Carcinoma in situ of testicular tissue adjacent to malignant germ-cell tumors: a study of 105 cases.Cancer, 47, 2660 (1981).

    Google Scholar 

  18. Javadpour, N.: Improved staging for testicular cancer using biologic tumor markers: a prospective study.J. Urol., 124, 58 (1980).

    Google Scholar 

  19. Kánya, A., Vadon, G., Engloner, L., Bucsky, P.: Primary retroperitoneal teratoma in adulthood (in Hungarian)Orv. Hetil. 123, 795 (1982).

    Google Scholar 

  20. Kitajima, K., Endo, K., Okada, K., Kishimoto, T.: Double staining of indirect immunoperoxidase method for HCG and AFP in the human testicular tumor.Acta Histochem. (Jena),16, 148 (1983).

    Google Scholar 

  21. Kleinsmith, L. J., Pierce, G. B.: Multipotentiality of single embryonal carcinoma cells.Cancer Res., 24, 1544 (1964).

    Google Scholar 

  22. Kurman, R. J., Scardino, P. T., McIntire, K. R., Waldmann, T. A., Javadpour, N.: Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique. A new approach to classification utilizing tumor markers.Cancer, 40, 2136 (1977).

    Google Scholar 

  23. Magasi, P., Vydra, G.: The complex treatment of testicular tumors (in Hungarian).Urol. Nephrol. Szle, 9, 55 (1982).

    Google Scholar 

  24. Marin-Padilla, M.: Histopathology of the embryonal carcinoma of the testes. Embryological evaluation.Arch. Pathol., 85, 614 (1968).

    Google Scholar 

  25. Monaghan, P., Raghavan, D., Neville, A. M.: Ultrastructural studies of xenografted human germ cell tumors.Cancer, 49, 683 (1982).

    Google Scholar 

  26. Mostofi, F. K.: Pathology of germ cell tumors of testis. A progress report.Cancer 45, 1735 (1980).

    Google Scholar 

  27. Mostofi, F. K., Sobin, L. H.: International Histological Classification of Tumors of Testes (No. 16). World Health Organization, Geneva 1977.

    Google Scholar 

  28. Munro, A. J., Duncan, W., Webb, J. N.: Extragonadal presentations of germ cell tumours.Br. J. Urol., 44, 547 (1983).

    Google Scholar 

  29. Müller, J., Skakkebaek, N. E.: Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis.Int. J. Androl., Suppl.4, 211 (1981).

    Google Scholar 

  30. Needham, J.: Biochemistry and Morphogenesis. Cambridge University Press, 1942.

  31. Nielsen, H., Nielsen, M., Skakkebaek, N. E.: The fine structure of a possible carcinomain-situ in the seminiferous tubules in the testis of four infertile men.Acta Pathol. Microbiol. Scand. [A],82, 235 (1974).

    Google Scholar 

  32. Nochomovitz, L. E., Rosai, J. Current concepts on the histogenesis, pathology and immunochemistry of germ cell tumors of the testis.Pathol. Annu., 13, 327 (1978).

    Google Scholar 

  33. Parkinson, C., Beilby, J. O. W.: Features of prognostic significance in testicular germ cell tumours.J. Clin. Pathol., 30, 113 (1977).

    Google Scholar 

  34. Parkinson, C., Beilby, J. O. W.: Testicular germ cell tumours: should current classification be revised?Invest. Cell. Pathol., 3, 135 (1980).

    Google Scholar 

  35. Pierce, G. B., Jr.: Ultrastructure of human testicular tumors.Cancer, 19, 1963 (1966).

    Google Scholar 

  36. Pierce, G. B., Abell, M. R.: Embryonal carcinoma of the testis.Pathol. Annu., 5, 27 (1970).

    Google Scholar 

  37. Pintér, J., Szokoly, V., Sallay, Zs.: Treatment of testicular tumours.Acta Chir. Acad. Sci. Hung., 20, 369 (1979).

    Google Scholar 

  38. Pugh, R. C. B. (ed.): Pathology of the Testis. Blackwell Scientific Publications, Oxford 1976.

    Google Scholar 

  39. Raghavan, D., Heyderman, E., Monaghan, P., Gibbs, J., Ernoslahti, M., Peckham, M. J., Neville, A. M.: Hypothesis: when is a seminoma not a seminoma?J. Clin. Pathol., 34, 123 (1981).

    Google Scholar 

  40. Raghavan, D., Sullivan, A. L., Peckham, M. J., Neville, A. M.: Elevated serum alphafetoprotein and seminoma. Clinical evidence for a histologic continuum?Cancer, 50, 982 (1982).

    Google Scholar 

  41. Rowland, R. G., Weisman, D., Williams, S. D., Einhorn, L. H., Klatte, E. C., Donohue, J. P.: Accuracy of preoperative staging in stages A and B nonseminomatous germ cell testis tumors.J. Urol., 127, 718 (1982).

    Google Scholar 

  42. Schmidt, C. G.: Hodentumoren — ein Durchbruch?Schweiz. Med. Wochenschr., 113, 1293 (1983).

    Google Scholar 

  43. Schütte, B., Holstein, A. F., Schulze, C., Schirren, C.: Zur Problematik der Früherkennung eines Seminoms. Nachweis von Tumorzellen in der Biopsie aus den Hoden von 5 Patienten mit Oligozoospermie.Andrologia, 13, 521 (1981).

    Google Scholar 

  44. Skakkebaek, N. E.: Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men.Histopathology, 2, 157 (1978).

    Google Scholar 

  45. Skakkebaek, N. E., Berthelsen, J. G.: Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory.Int. J. Androl., Suppl.4, 26 (1981).

    Google Scholar 

  46. Speers, W. C.: Conversion of malignant murine embryonal carcinomas to benign teratomas by chemical induction of differentiation in vivo.Cancer Res., 42, 1843 (1982).

    Google Scholar 

  47. Stevens, L. S.: Environmental influence on experimental teratocarcinogenesis in testes of mice.J. Exp. Zool., 174, 407 (1970).

    Google Scholar 

  48. Stiller, D., Katenkamp, D., Pressler, H., Kosmehl, H.: Keimzelltumoren des Hodens: Histologische Klassifikation von 552 Fällen entsprechend der WHO-Nomenklatur.Zentralbl. Allg. Pathol., 128, 85 (1983).

    Google Scholar 

  49. Szymendera, J. J., Zborzil, J., Sikorowa, L., Kaminska, J. A., Gadek, A.: Value of five tumor markers (AFP, CEA, HCG, HPL and Sp1) in diagnosis and staging of testicular germ cell tumors.Oncology, 38, 222 (1981).

    Google Scholar 

  50. Takei, Y., Pearl, G. S.: Ultrastructural study of intracranial yolk sac tumor: with special reference to the oncologic phylogeny of germ cell tumors.Cancer, 48, 2038 (1981).

    Google Scholar 

  51. Talerman, A.: Spermatocytic seminoma. Clinicopathological study of 22 cases.Cancer, 45, 2169 (1980).

    Google Scholar 

  52. Talerman, A.: Endodermal sinus (yolk sac) tumor elements in testicular germ-cell tumors in adults: comparison of prospective and retrospective studies.Cancer, 46, 1213 (1980).

    Google Scholar 

  53. Tayler, C. R., Kurman, R. J., Warner, N. E.: The potential value of immunohistologic techniques in the classification of ovarian and testicular tumors.Hum. Pathol. 9, 417 (1978).

    Google Scholar 

  54. Teilum, G.: Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary.Acta Path. Microbiol. Scand., 64, 407 (1965).

    Google Scholar 

  55. Teilum, G.: Special Tumours of Ovary and Testis. Comparative Pathology and Histological Identification. Second edition. Munksgaard, Copenhagen 1976.

    Google Scholar 

  56. Thurzó, R., Pintér, J., Nagy, L.: Malignant tumors of the testis in adults (in Hungarian).Magy. Onkol., 9, 87 (1965).

    Google Scholar 

  57. Tóth, I., Bodrogi, I., Baki, M., Eckhardt, S.: Evaluation of serum α1-fetoprotein examination of patients treated with adjuvant and curative chemotherapy because of testicular tumors (in Hungarian).Orv. Hetil., 124, 2661 (1983).

    Google Scholar 

  58. Willis, R. A.: Pathology of Tumours. Fourth edition. Butterworths, London 1967.

    Google Scholar 

  59. Wurster, K., Hedinger, Ch., Meienberg, O.: Orchioblastomartige Herde in Hodenteratomen von Erwachsenen. Zur Frage der Eigenständigkeit des Orchioblastoms.Virchows Arch. [Abt. A. Pathol. Anat.],357, 231 (1972).

    Google Scholar 

  60. Zeuthen, J.: Human teratocarcinoma cell lines. A review.Int. J. Androl., Suppl.4, 61 (1981).

    Google Scholar 

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  1. Institute of Pathology, Postgraduate Medical School, Budapest, Hungary

    F. Kiss & J. Juhász

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Kiss, F., Juhász, J. Testicular germ cell tumours. International Urology and Nephrology 17, 85–95 (1985). https://doi.org/10.1007/BF02089407

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