Abstract
Forty-six patients with marked renal failure and anemia underwent androgen therapy (up to 500 mg/week), as well as intravenous injections of iron preparations (600–800 mg/month) and hemotransfusions (2500 ml/month) for 4 month. Ferro-kinetic indices, total marrow cellularity and erythrocyte and hemoglobin levels were determined at the end of therapy.
Androgens were responsible for the increase in Hb level by 1.2 g%. High total bone marrow cellularity was observed in these patients (27.4±3.2×109 cells/kg, compared with 14.1±1.4×109 cells/kg in normal individuals). Hemotransfusions resulted in a decrease of Hb level by 1.3 g% and total bone marrow cellularity to 8.3±2.2×109 cells/kg. Ferrokinetic indices became poor. The data obtained are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Editorial: Anaemia in chronic renal failure.Lancet, I, 164 (1975).
De Gowing, R. L., Levander, A. R., Ferland, M., Charleston, D., Gottscholk, A.: Erythropoiesis and erythropoietin in patients with chronic renal failure treated with hemodialysis and testosterone.Ann. Intern. Med., 72, 913 (1970).
Richardson, J. E., Weinstein, M. B.: Erythropoietic response of dialyzed patients to testosterone administration.Ann. Intern. Med., 73, 403 (1970).
Shalson, S., Koch, K. M., Opperman, F., Patina, W. D., Schaeppe, W.: Testosterone therapy for anaemia in maintenance dialysis.Brit. Med. J., 3, 212 (1971).
Hartitzsch, B. von, Kerr, D. N. S.: Response to parenteral iron with and without androgen therapy in patients undergoing regular haemodialysis.Nephron, 17, 430 (1976).
Hartitzsch, B. von, Kerr, D. N. S., Marley, C., Marks, B.: Androgens in the anaemia of chronic renal failure.Nephron, 18, 13 (1977).
Fried, W., Jonasson, O. M., Lang, G. R., Schwartz, F. D.: Androgen therapy in patients with and without kidneys undergoing hemodialysis.Ann. Intern. Med., 78, 822 (1973).
Ryabov, S. I., Shostka, G. D.: Molecular-genetic aspects of erythropoiesis. Leningrad 1973.
Ryabov, S. I., Shotska, G. D.: Erythropoiesis in renal failure. In: Chronic Renal Failure. Leningrad 1976, p. 220.
Suit, H. D.: A technique for estimating the bone marrow cellularity in vivo using59Fe.J. Clin. Path., 10, 267 (1957).
Skarberg, K. O.: Cellularity and cell proliferation rates in human bone marrow.Acta Med. Scand., 195, 291 (1974).
Finch, C. A., Denbelbeiss, K., Cook, J. D., Fischbach, J. W.: Ferrokinetics in man.Medicine, 49, 17 (1970).
Stewart, W. K., Fleming, L. W., Shepard, A. M. M.: Hemoglobin and serum iron response to periodic intravenous iron-dextran infusions during maintenance haemodialysis.Nephron, 17, 121 (1976).
Nielsen, B.: Anemia in the chronic dialysis patient. In: Chronic Hemodialysis, its Consequences and Results of the Treatment. Gambro Symposium, Moscow 1977, Vol. 7, p. 17.
Zucher, S., Lysik, R. M., Mohammal, G.: Erythropoiesis in chronic renal disease.J. Lab. Clin. Med., 88, 528 (1976).
Hadjian, A. J., Spivak, J. L., Kowarski, A., Dickerman, H. W., Migeon, C. J.: Stereospecific tissue uptake and nuclear accumulation of testosterone in the development of the mouse erythropoietic spleen.Blood, 47, 571 (1976).
Hara, H., Ogawa, M.: Erythropoietic precursors in mice under erythropoietic stimulation and suppression.Exp. Hematol., 5, 1941 (1977).
Singer, J. W., Adamson, J. W.: Steroids and hematopoiesis.Blood, 48, 855 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ryabov, S.I., Shostka, G.D. & Vinogradova, T.V. Androgen therapy for anemia in renal failure. International Urology and Nephrology 12, 161–167 (1980). https://doi.org/10.1007/BF02089356
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02089356