Conclusions
Guinea pigs immunized withC. albicans may develop tuberculin hypersensitivity, possibly depending upon the strain ofC. albicans used for immunization. An animal colony found to be grossly contaminated withC. albicans showed a concomitant increase in positive Candida and tuberculin reactions in normal animals. The organism was isolated from the intestinal tract of a majority of these animals. The possibility of concurrent, unobserved contamination of guinea pigs with members of the mycobacteria cannot be excluded. Other animal colonies were noted to have varying numbers of carriers ofC. albicans, depending largely on the age and conditions under which the animals were housed.
The ingestion ofC. albicans by guinea pigs seems capable of rendering these animals hypersensitive to this organism in approximately three weeks. The presence of the organism in the gut does not disturb the normal health or activity of the animals, and would appear to be an inapparent infection which can be detected by skin testing procedures.
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Vogel, R.A., Koger, M., Johnson, M. et al. Tuberculin hypersensitivity associated with immunization of Guinea pigs with candida albicans and the presence of this organism in normal Guinea pigs. Mycopathologia et Mycologia Applicata 16, 117–124 (1962). https://doi.org/10.1007/BF02089128
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DOI: https://doi.org/10.1007/BF02089128