Digestive Diseases and Sciences

, Volume 39, Issue 3, pp 661–662 | Cite as

Could immunostimulant drugs be useful in apparently medically refractory Crohn's disease?

  • Gerardo Nardone
  • Gabriele Budillon
Case Report
  • 13 Downloads

Key words

Crohn's disease thymostimulin 

References

  1. 1.
    Levine DS, Fischer SH, Christie DL, Haggitt RC, and Ochs H: Intravenous immunoglobulin therapy for active, extensive, and medically refractory idiopathic ulcerative or Crohn's colitis. Am J Gastroenterol 87:91–100, 1992Google Scholar
  2. 2.
    Geier DL, Miner PB: New therapeutic agents in the treatment of inflammatory bowel disease. Am J Med 93:199–208, 1992PubMedGoogle Scholar
  3. 3.
    Sacher DB, Rubin KP, Gumaste V: Levamisole in Crohn's disease: A randomized, double-blind, placebo-controlled clinical trial. Am J Med 82:536–539, 1987PubMedGoogle Scholar
  4. 4.
    James SP, Neckers LM, Graeff AS, Cossman J, Balch CM, Strober W: Suppression of immunoglobulin synthesis by lymphocyte subpopulation in patients with Crohn's disease. Gastroenterology 86:1510–1515, 1984PubMedGoogle Scholar
  5. 5.
    Raedler A, Fraenkel S, Klose G, Seyfarth K, Thieie HG: Involvement of the immune system in the pathogenesis of Crohn's disease: Expression of the T9 antigen on peripheral immunocytes correlates with the severity of the disease. Gastroenterology 88:978–983, 1985PubMedGoogle Scholar
  6. 6.
    Snook J: Are the inflammatory bowel disease autoimmune disorders? Gut 31:961–963, 1990PubMedGoogle Scholar
  7. 7.
    Fiocchi C, Roche JK, Michener WM: High prevalence of antibodies to intestinal epithelial antigens in patients with inflammatory bowel disease and their relatives. Ann Intern Med 110:786–794, 1989PubMedGoogle Scholar
  8. 8.
    Targan S, Saxon A, Landers C, Ganz T, Shanahn F: Serum anti-neutrophil cytoplasmic autoantibodies distinguish ulcerative colitis from Crohn's disease patients. Gastroenterology 96:A505, 1989Google Scholar
  9. 9.
    Fiocchi C: Lymphokines and intestinal immune response: Role in inflammatory bowel disease. Immunol Invest 18:91–102, 1989PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Gerardo Nardone
    • 1
  • Gabriele Budillon
    • 1
  1. 1.From the Cattedra di GastroenterologiaUniversità degli Studi di Napoli Federico IINapoliItaly

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