Role of gastric mucosal blood flow in gastroprotective effect of novel xanthine derivative
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The effect of 3-ethyl-1-(6-hydroxy-6-methylheptyl)-7-propylxanthine (A90 6119) on 40% ethanol-induced gastric lesions and gastric mucosal blood flow was investigated in rats. Gastric mucosal blood flow was measured by the hydrogen gas clearance technique and the test compounds and vehicle were administered intraduodenally. A90 6119 dose-dependently increased gastric mucosal blood flow and decreased gross and histologic gastric mucosal injury induced by 40% ethanol. Both the gastric mucosal blood flow and protective effects of A90 6119 were completely attenuated by pretreatment with indomethacin. The findings demonstrate that A90 6119 protects against ethanol-induced gastric injury, and this effect involves stimulation of endogenous prostaglandin synthesis and an increase in gastric mucosal blood flow.
Key wordsxanthine derivative gastric mucosal blood flow gastroprotection endogenous prostaglandin
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- 1.Roth JA, Ivy AC: The effect of caffeine upon gastric secretion in the dog, cat and man. Am J Physiol 141:454–459, 1944Google Scholar
- 6.Tanaka T, Bickel M, Herling AW, Sakurai M, Goto M, Hayashi S: Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric acid secretion in rats. Arzneim-Forsch/Drug Res 39:689–694, 1989Google Scholar
- 7.Tanaka T, Morioka Y, Gebert U: Effect of a novel xanthine derivative on experimental ulcers in rats. Arzneim-Forsch/Drug Res 43:558–562, 1993Google Scholar
- 9.Konturek SJ, Radecki T, Brozozowski T, Piasticki I, Dembinska-Kiec A, Zmuda A: Gastric cytoprotection by prostaglandins, ranitidine and probanthine in rats. Role of endogenous prostaglandins. Scand J Gastroenterol 16:7–12, 1981Google Scholar
- 12.Guth PH, Paulsen G, Nagata H: Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: Effect of prostaglandin cytoprotection. Gastroenterology 87:1083–1090, 1984Google Scholar
- 14.Guth PH: Gastric blood flow in ethanol injury and prostaglandin cytoprotection. Scand J Gastroenterol (Suppl 125) 21:86–91, 1986Google Scholar
- 22.Tanaka T, Taché Y, Guth PH: Involvement of vagal pathway in the anti-secretory effect of a novel xanthine derivative. Eur J Pharmacol (in press)Google Scholar
- 25.Guth PH, Leung FW: Physiology of the gastric circulation.In LR Johnson (ed). Physiology of the Gastrointestinal Tract. New York, Raven Press, 1987, pp 1031–1053Google Scholar
- 26.Silen W: Gastric mucosal defense and repair.In LR Johnson (ed). Physiology of the Gastrointestinal Tract. New York, Raven Press, 1987, pp 1055–1069Google Scholar