Comparative effects of growth hormone on water and ion transport in rat jejunum, ileum, and colon


Specific growth hormone (GH) receptors are located along the entire rat intestine. We have recently shown that GH induces water and ion absorption in the rat ileum. This raises the possibility that GH regulates water and ion transport throughout the intestine. To test this, we have evaluated the effects of GH administration on jejunal, ileal, and colonic water and ion transport, by thein vivo rat perfused intestine, andin vitro, in corresponding segments of intestine mounted in Ussing chambers.In vivo, GH increased water absorption by 250%, 180%, and 80% over baseline in the jejunum, ileum, and colon, respectively. The effect had similar kinetics in the three intestinal regions.In vitro, serosal GH administration induced a decrease in short-circuit current, consistent with an absorptive effect. The effect showed a proximal to distal decreasing pattern. These findings suggest that GH plays a role in the body fluid homeostatic control, promoting water and ion absorption.

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Corresponding author

Correspondence to Dr. Alfredo Guarino MD.

Additional information

This work was supported in part by a grant from the Ministero della Sanità AIDS research project 1995, program 9205-35, and by a grant from CNR, no. 94. 02505 CT04.

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Canani, R.B., Iafusco, M., Russo, R. et al. Comparative effects of growth hormone on water and ion transport in rat jejunum, ileum, and colon. Digest Dis Sci 41, 1076–1081 (1996).

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Key words

  • growth hormone
  • ion transport
  • rat intestine
  • intestinal perfusion