Digestive Diseases and Sciences

, Volume 39, Issue 7, pp 1441–1445 | Cite as

Response of gastric fundus to rectal distension in healthy persons

  • Jaime Zighelboim
  • Nicholas J. Talley
  • Sidney F. Phillips
Original Articles

Abstract

We aimed to record fundic motor activity in man using the barostat to ascertain if fundic motility is affected by rectal distension. The distal ends of two barostat tubes were placed in the gastric fundus and rectum in 10 healthy volunteers. The gastric bag was first inflated to a constant pressure level that recorded phasic motor activity as changes in volume of the air-filled bag. Baseline motor activity was recorded before, during, and after a 15-min period of constant rectal distension that was clearly perceived by all subjects but was not painful. In all subjects, continuous phasic volume changes, reflecting fundic motor activity, were recorded at a rate of 1–3/min. During rectal distension, a consistent change in mean contractile force of these phasic volume events was not detected; a decrease of more than 30% occurred in only three subjects. We conclude that fundic phasic volume changes are recordable by the barostat, but these are not substantially inhibited by rectal distension.

Key words

rectal distension fundic motility rectofundic response barostat 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wright SH, Snape WJ, Battle W, Cohen S, London RL: Effect of dietary components on gastrocolonic response. Am J Physiol 238:G228-G232, 1980Google Scholar
  2. 2.
    Snape WJ, Wright SH, Battle WM, Cohen S: The gastrocolonic response: Evidence for a neural mechanism. Gastroenterology 77:1235–1240, 1979Google Scholar
  3. 3.
    Spiller RC, Trotman IF, Higgins BE, Ghatei MA, Grimble GK, Lee YC, Bloom SR, Misiewicz JJ, Silk DB: The ileal brake: Inhibition of jejunal motility after ileal fat perfusion in man. Gut 25:365–374, 1984Google Scholar
  4. 4.
    Youle MS, Read NW: Effect of painless rectal distension on gastrointestinal transit of solid meal. Dig Dis Sci 29:902–906, 1984Google Scholar
  5. 5.
    Kellow JE, Gill RC, Wingate DL: Modulation of human upper gastrointestinal motility by rectal distention. Gut 28:864–868, 1987Google Scholar
  6. 6.
    Tjeerdsma HC, Smout AJPM, Akkermans LMA: Voluntary suppression of defecation delays gastric emptying. Dig Dis Sci 38:832–836, 1993Google Scholar
  7. 7.
    Van Der Sijp JRM, Kamm MA, Nightingale JMD, Britton KE, Granowska M, Mather SJ, Akkermans LMA, Lennard-Jones JE: Disturbed gastric and small bowel transit in severe idiopathic constipation. Dig Dis Sci 38:837–844, 1993Google Scholar
  8. 8.
    Aspiroz F, Malagelada JR: Pressure activity patterns in the canine proximal stomach; response to distention. Am J Physiol 247:G265-G272, 1984Google Scholar
  9. 9.
    Azpiroz F, Malagelada J-R: Gastric tone measured by an electronic barostat in health and postsurgical gastroparesis. Gastroenterology 92:934–943, 1987Google Scholar
  10. 10.
    Azpiroz F, Malagelada J-R: Physiologic variations in canine gastric tone measured by an electronic barostat. Am J Physiol 248:G229-G237, 1985Google Scholar
  11. 11.
    Azpiroz F, Malagelada J-R: Perception and reflex relaxation of the stomach in response to gut distention. Gastroenterology 98:1193–1198, 1990Google Scholar
  12. 12.
    Rouillon JM, Azpiroz F, Malagelada J-R: Sensorial and intestinointestinal reflex pathways in the human jejunum. Gastroenterology 101:1606–1612, 1991Google Scholar
  13. 13.
    Stivland T, Camilleri M, Vassallo M, Proano M, Rath D, Brown M, Thomforde G, Pemberton J, Phillips S: Scintigraphic measurement of regional gut transit in idiopathic constipation. Gastroenterology 101:107–115, 1991Google Scholar
  14. 14.
    Steadman CJ, Phillips SF, Camilleri M, Haddad AC, Hanson RB: Variation of muscle tone in the human colon. Gastroenterology 101:373–381, 1991Google Scholar
  15. 15.
    Bell AM, Pemberton JH, Hanson RB, Zinsmeister AR: Variations in muscle tone of the human rectum: Recordings with an electromechanical barostat. Am J Physiol 260:G17-G25, 1991Google Scholar
  16. 16.
    Steadman CJ, Phillips SF, Camilleri M, Talley NJ, Haddad A, Hanson R: Control of muscle tone in the human colon. Gut 33:541–546, 1992Google Scholar
  17. 17.
    Mearin F, Cucala M, Azpiroz F, Malagelada J-R: The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 101:999–1006, 1991Google Scholar
  18. 18.
    Akervall S, Fasth S, Nordgren S, Oresland T, Hulten L. Rectal reservoir and sensory function studied by graded isobaric distention in normal man. Gut 30:496–502, 1989Google Scholar
  19. 19.
    Camilleri M: Study of human gastroduodenojejunal motility: Applied physiology in clinical practice. Dig Dis Sci 38:785–794, 1993Google Scholar
  20. 20.
    Mintchev MP, Kingma YJ, Bowes KL: Accuracy of cutaneous recordings of gastric electrical activity. Gastroenterology 104:1273–1280, 1993Google Scholar
  21. 21.
    Moragas G, Azpiroz F, Pavia J, Malagelada JR: Relations among intragastric pressure, postcibal perception, and gastric emptying. Am J Physiol 264:G1112-G1117, 1993Google Scholar
  22. 22.
    Ness TJ, Gebhart GF: Interactions between visceral and cutaneous nociception in the rat. J Neurophysiol 66:20–39, 1991Google Scholar
  23. 23.
    Leek BF: Abdominal and pelvic receptors. Br Med Bull 33:163–168, 1977Google Scholar
  24. 24.
    Cottrell DF, Iggo A: Tension receptors with vagal afferent fibres in the proximal duodenum and pyloric sphincter of sheep. J Physiol (London) 354:457–475, 1984Google Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Jaime Zighelboim
    • 1
  • Nicholas J. Talley
    • 1
  • Sidney F. Phillips
    • 1
  1. 1.From the Division of Gastroenterology and Internal MedicineMayo Clinic and Mayo FoundationRochester

Personalised recommendations