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Bone disorders following total gastrectomy

Digestive Diseases and Sciences volume 39, pages 2511–2515 (1994)Cite this article

Abstract

Bone disorders following gastrectomy were studied by measuring absolute and relative bone mineral density of the Wards triangle, serum 1,25-(OH)2-D, alkaline phosphatase, and total serum calcium. The subjects were 20 males who had undergone total gastrectomy not more than three months previously (group A1). Seventeen of these patients were reviewed three years later (group A2). Absolute and relative bone density were significantly lower in group A2 than in A1 (0.52 ± 0.011 g/cm2 versus 0.6 ± 0.014 g/cm2,P<0.01 and 85.5 ± 1.4% age-matched control versus 95 ± 1.3%,P<0.01). 1,25-(OH)2-D was significantly lower in group A2 than in group A1 (14.3 ± 0.97 pg/ml versus 20.6 ± 1.02 pg/ml,P<0.01). There was no difference in alkaline phosphatase and calcium serum concentration. The mean weight loss was 6.26 ± 0.57% over the follow-up period, and weight loss correlated with absolute and relative bone density (r=−0.74,P<0.01). There was a positive correlation between 1,25-(OH)2-D and absolute or relative bone density (r=0.67,r=0.62 andP<0.01). These data suggest that bone density decrease has already occurred three years after total gastrectomy and is positively correlated to 1,25-(OH)2-D deficiency. As no differences in serum alkaline phosphatase and serum calcium concentration were found, these factors are of little value for the early detection of postgastrectomy bone disorders, whereas weight loss is a valuable screening parameter.

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Affiliations

  1. Department of Surgery, Creighton University, Omaha, Nebraska

    Gerold Wetscher MD, Elizabeth Redmond MD, Christine Watfah MD, Galen Perdikis MD, Michael Gadenstätter MD & Rudolph Pointner MD

  2. Department of Nuclear Medicine, University of Innsbruck, Innsbruck, Austria

    Gerold Wetscher MD, Elizabeth Redmond MD, Christine Watfah MD, Galen Perdikis MD, Michael Gadenstätter MD & Rudolph Pointner MD

  3. Department of Surgery, Zell am See, Austria

    Gerold Wetscher MD, Elizabeth Redmond MD, Christine Watfah MD, Galen Perdikis MD, Michael Gadenstätter MD & Rudolph Pointner MD

  4. 2nd Department of Surgery, University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    Gerold Wetscher MD, Elizabeth Redmond MD, Christine Watfah MD, Galen Perdikis MD, Michael Gadenstätter MD & Rudolph Pointner MD

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  1. Gerold Wetscher MD
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  2. Elizabeth Redmond MD
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  3. Christine Watfah MD
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  4. Galen Perdikis MD
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  5. Michael Gadenstätter MD
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  6. Rudolph Pointner MD
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Wetscher, G., Redmond, E., Watfah, C. et al. Bone disorders following total gastrectomy. Digest Dis Sci 39, 2511–2515 (1994). https://doi.org/10.1007/BF02087683

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  • DOI: https://doi.org/10.1007/BF02087683

Key words

  • gastrectomy
  • bone disorders
  • vitamin D deficiency