Digestive Diseases and Sciences

, Volume 39, Issue 5, pp 1090–1098 | Cite as

Dyspepsia in healthy blood donors

Pattern of symptoms and association withHelicobacter pylori
  • Gerald Holtmann
  • Harald Goebell
  • Marianne Holtmann
  • Nicholas J. Talley


WhetherHelicobacter pylori is causally linked to dyspepsia remains controversial. The aims of this study were to assess in healthy blood donors the prevalence of dyspepsia and dyspepsia subgroups, determine ifH. pylori is associated with different categories of dyspeptic symptoms, and evaluate the association between dyspepsia and nicotine, alcohol, and analgesic use. Consecutive blood donors (N=180) who had no clinical evidence of organic disease were included. Abdominal symptoms were measured by means of a standardized questionnaire that has been previously validated. Subjects with dyspepsia (defined as pain localized to the upper abdomen) were further subdivided into those with ulcer-like, dysmotility-like, reflux-like, or nonspecific dyspepsia. A total of 65 subjects reported abdominal pain or discomfort during the prior 12 months [36.1%, 95% confidence interval (CI) 29.1–43.1]; 44 subjects (24.4%, 95% CI 18.2–30.7) had dyspepsia. Dysmotility-like, reflux-like, and ulcer-like symptoms were reported by 19.4% (95% CI 13.7–25.2), 17.2% (95% CI 11.7–22.7), and 16.7% (95% CI 11.2–22.1) of subjects with dyspepsia, respectively. Fifty-seven subjects (31.7%, 95% CI 24.9–38.5) wereH. pylori positive; 26% of subjects withH. pylori and 24% withoutH. pylori had dyspepsia (P>0.50). The seroprevalence ofH. pylori was also similar among the different categories of dyspepsia. We conclude that infection withH. pylori is not associated with abdominal complaints in otherwise healthy subjects.

Key words

aspirin functional dyspepsia Helicobacter pylori irritable bowel syndrome 


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Gerald Holtmann
    • 3
    • 1
    • 2
  • Harald Goebell
    • 3
    • 1
    • 2
  • Marianne Holtmann
    • 3
    • 1
    • 2
  • Nicholas J. Talley
    • 3
    • 1
    • 2
  1. 1.Department of Transfusion MedicineUniversity of EssenGermany
  2. 2.University of SydneySydneyAustralia
  3. 3.Department of Internal Medicine, Division of GastroenterologyUniversity of EssenEssenGermany

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