Abstract
A total of 26 cases of “nonspecific” erosions and ulcers of the colonic mucosa are reported. The most common causes were previous abdominal irradiation or ischemic disease due to arteriosclerosis. The lesions were localized to all segments of the colon. Of the 26 cases, five (19.2%) had erosions (ie, not penetrating beyond the muscularis mucosae) and the remaining 21, ulcers (ie, penetrating beyond the muscularis mucosae). In seven of the 26 cases (26.9%) more than one ulcer was found in the same specimen. Erosions may heal completely by epithelial regeneration (ie,restitutio ad integrum) while ulcers usually heal by replacing scarring tissue. Thus, the two lesions may not be clinically synonymous. The relatively high proportion of erosions among nonspecific ulcerations of the colonic mucosa has not been previously pointed out in the literature.
Similar content being viewed by others
References
Cruveilhier J: Un beau cas de cicatrisation d'un ulcere de l'intestin grele datant d'une dozaine d'annees. Bull Soc Anat 7:102–103, 1832
Mahoney TJ, Bubrick MP, Hitchcock CR: Nonspecific ulcers of the colon. Dis Colon Rectum 21(8):623–626, 1978
Blundell CR, Earnest DL: Idiopathic cecal ulcer diagnosis by colonoscopy followed by nonoperative management. Dig Dis Sci 25:494–503, 1980
Shallman RW, Kuehner M, Williams GH, Sajjad S, Sautter R: Benign cecal ulcers. Dis Colon Rectum 28:732–737, 1985
Bayerdörffer E, Sommer GA, Ottenjann R: Solitary colonic ulcers. Gastrointest Endosc 32:6–9, 1986
Shah NC, Ostrov AH, Cavallero JB, Rodgers JB: Benign ulcers of the colon. Gastrointest Endosc 32:102–104, 1986
Lipton S, Reisman ED: Simple ulcer of the cecum. Ann Surg 134:279–281, 1951
Bernardino ME, Lawson TL: Discrete colonic ulcers associated with oral contraceptives. Am J Dig Dis 21(6):503–506, 1976
Makoui C, Chakravorty RC, Wilson WH: Nonspecific ulcer of the ascending colon. Am Soc Col Rect Surg 22(4):256–259, 1979
Uribe A, Johansson C, Slezak P, Rubio C: Ulcerations of the colon associated with naproxen and acetylsalicylic acid treatment. Gastrointest Endosc 32:3–4, 1986
Whitehead R: Other forms of colitis and non-specific ulcers.In Gastrointestinal and Oesophageal Pathology. R Whitehead (ed). Edinburgh, Churchill Livingstone, 1989, pp 514–521
Farrell DJ, Bennett MK: Dieulafoy's vascular malformation as a cause of large intestinal bleeding. J Clin Pathol 45:363–366, 1992
Rubio CA, Kollberg B, Johansson C, Rodensjö M: Acute gastric erosions in the rat. I. Microangiography. Acta Rad Oncol 20(5):345–349, 1981
Uribe A, Goobar J, Rubio CA: Colonic ulcerations in Wegener's granulomatosis. J Rheum 18:1429–1430, 1991
Hellstrom PM, Rubio CA, Odar-Cederlof I, Slezak P: Ischemic colitis of the cecum after renal transplantation masquerading as malignant disease. Dig Dis Sci 36:1644–1648, 1991
McKelvie GB: Simple cecal ulceration and diverticulitis of the cecum. Scot Med J 6:567–568, 1961
Barlow D: “Simple” ulcers of the cecum, colon and rectum. Br J Surg 28:575–579, 1941
Mark HI, Ballinger WF II: Nonspecific ulcer of the colon: Report of a case and review of 51 cases from the literature. Am J Gastroenterol 41:266–270, 1964
Smithwick W III, Anderson RP, Ballinger WF II: Nonspecific ulcer of the colon. Arch Surg 97:133–135, 1968
Kurtz MD: Colonoscopic diagnosis of nonspecific ulcer of the colon. Gastrointest Endosc 23:90–93, 1976
Rotterdam H, Sommers SC: Biopsy Diagnosis of the Digestive Tract. New York, Raven Press, 1981, pp 391–392
Ona FV, Allende HD, Vivenzio R, Zaky DA, Nadaraja N: Diagnosis and management of nonspecific colon ulcer. Arch Surg 117:888–894, 1982
Author information
Authors and Affiliations
Additional information
This study was supported by grants from the Karolinska Institute.
Rights and permissions
About this article
Cite this article
Rubio, C.A., Nydahl, S. “Nonspecific” erosions and ulcers of the colonic mucosa. Digest Dis Sci 39, 821–826 (1994). https://doi.org/10.1007/BF02087429
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02087429