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Effect of constant light on rhythmic gastric functions in fasting rats

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Abstract

The effects of four weeks of continuous illumination (LL), a subacute stress, on gastric mucosal endogenous aggressive and defensive factors were studied. Young male Sprague-Dawley rats were used with two different illumination regimens: LL and 12 hr light/12 hr dark (LD). At the end of three to four weeks of either regimen of illumination, gastric acid secretion, pepsin secretion, mucus secretion, and potential difference (PD) were studied. All gastric parameters, except mucus secretion, were significantly reduced by LL. The reduction in acid secretion (13.3%) was not significant after Bonferroni correction for the fourt tests Pepsin secretion and PD were 27.9% and 24.6% less, respectively. These differences were significant after Bonferroni correction. The LD rats showed significant circadian rhythms for acid, mucus, and pepsin secretion. The LL rats showed significant rhythmicity for these same parameters with period lengths different from 24 hr. Gross inspection of the gastric mucosa indicated that 69.8% of the LL rats had lesion scores of 1.0 or higher, while none of the LD rats had scores above 0.5.

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Authors and Affiliations

  1. From the Departments of Medicine and Surgery, Salt Lake Veterans Affairs Medical Center, and Division of Gastroenterology, University of Utah School of Medicine, 84132, Salt Lake City, Utah

    Kenneth R. Larsen PhD, Paolo Barattini MD, Merril T. Dayton MD & John G. Moore MD

  2. Istituto di Fisiologia Umana, Pavia, Italy

    Kenneth R. Larsen PhD, Paolo Barattini MD, Merril T. Dayton MD & John G. Moore MD

Authors
  1. Kenneth R. Larsen PhD
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  2. Paolo Barattini MD
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  3. Merril T. Dayton MD
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  4. John G. Moore MD
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Additional information

The authors acknowledge the Salt Lake Veterans Administration Medical Center, Department of Research, for support of this study.

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Larsen, K.R., Barattini, P., Dayton, M.T. et al. Effect of constant light on rhythmic gastric functions in fasting rats. Digest Dis Sci 39, 678–688 (1994). https://doi.org/10.1007/BF02087408

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  • DOI: https://doi.org/10.1007/BF02087408

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