Studies on tableting properties of lactose
The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength.
Key wordsCompaction Consolidation Crushing strength Fragmentation Lactose Particle size Porosity Tablets
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- 6.Vromans H, De Boer AH, Bolhuis GK, Lerk CF, Kussendrager KD, Bosch H. Studies on tableting properties of lactose. Part II. Consolidation and compaction of different types of crystalline lactose. Pharm Weekbl [Sci] 1985;57:186–93.Google Scholar
- 11.Sheikh-Salem M, Fell JT. Compaction characteristics of mixtures of materials with dissimilar compaction mechanisms. Int J Pharm Tech Prod Manufac 1981;2: 19–22.Google Scholar
- 13.Shotton E, Ganderton D. The strength of compressed tablets, III. The relation of particle size, bonding and capping in tablets of sodium chloride, aspirin and hexamine. J Pharm Pharmacol 1961;13:144T-52T.Google Scholar
- 14.Hüttenrauch R. Über den Mechanismus des Korngrösseneffekts in der Tablettierung. Pharmazie 1977;32: 130–1.Google Scholar
- 18.Hersey JA, Bayraktar G, Shotton E. The effect of particle size on the strength of sodium chloride tablets. J Pharm Pharmacol 1907;19:24S-30S.Google Scholar
- 19.Alpar O, Hersey JA, Shotton E. The compression properties of lactose. J Pharm Pharmacol 1970;22:1S-7S.Google Scholar