International Urology and Nephrology

, Volume 17, Issue 3, pp 231–233 | Cite as

A rare enzyme deficiency causing formation of 2,8-dihydroxyadenine (purine body) calculi

  • P. Szőnyi
  • M. Berényi
  • J. Tóth


Deficiency in the enzyme adenine-phosphoribosyltransferase (APRT) has given rise to the formation of 2,8-dihydroxyadenine calculi, which are extremely rare. It is the first case of this kind reported in Hungary.


Public Health Enzyme Purine Enzyme Deficiency Rare Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Berényi, M.: Calculus analysis by an ultramicrochemical method (in Hungarian).Orv. Hetil., 114, 2852 (1974).Google Scholar
  2. 2.
    Berényi, M.: Urolithiasis (in Hungarian). Medicina, Budapest 1981.Google Scholar
  3. 3.
    Cartier, P., Hamet, M.: New metabolic illness. Deficiency in adenine phosphoribosyltransferase with 2,8-dihydroxyadenine lithiasis.C. R. Acad. Sci., 279, 883 (1974).Google Scholar
  4. 4.
    Joost, J.: Complete adenine phosphoribosyltransferase deficiency with 2,8-dihydroxyadenine stone formation. In: Sperling, O., Vahlensieck, W. (eds): Uric Acid Lithiasis. Steinkopff, Darmstadt 1981.Google Scholar
  5. 5.
    Joost, J., Doopler, W.: 2,8-Dihydroxyadenine stone in children.Urology, 20, 67 (1982).CrossRefPubMedGoogle Scholar
  6. 6.
    Reveilland, R. J., Daudon, M., Protat, M. F.: Lithiase 2,8-dihydroxyadeninique: un nouveau cas depiste par analyse infrarouge.Nouv. Presse Med., 8, 2695 (1979).PubMedGoogle Scholar
  7. 7.
    Simmonds, H. A.: 2,8-Dihydroxyadeninuria — or when is a uric acid stone not a uric acid stone?Clin. Nephrol., 12, 195 (1979).PubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó 1985

Authors and Affiliations

  • P. Szőnyi
    • 1
  • M. Berényi
    • 1
  • J. Tóth
    • 1
  1. 1.Department of UrologySemmelweis University Medical SchoolBudapestHungary

Personalised recommendations