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Influence of cyproterone acetate on the activity ofβ-glucuronidase in the hypothalamus and cerebral cortex of the male mouse

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Summary

Daily s.c. injections of cyproterone acetate greatly decrease the protein content andβ-glucuronidase activity in the mouse hypothalamus. These effects are reversible and the recovery capacity of the animal seems to be inversely related to the duration of antiandrogenic treatment.

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Authors and Affiliations

  1. Institute and Museum of Zoology, Faculty of Sciences, via Mezzocannone 8, I-80134, Napoli, Italy

    M. Milone, R. K. Rastogi, F. del Sorbo, A. Corvino & M. F. Caliendo

Authors
  1. M. Milone
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  2. R. K. Rastogi
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  3. F. del Sorbo
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  4. A. Corvino
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  5. M. F. Caliendo
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Additional information

Financial aid was given by CNR (finalized project ‘Biologia della Riproduzione’) and Ministry of Education. Thanks are also due to Prof. G. Chieffi for suggestions and to Mr R. Auriemma for maintenance of experimental animals.

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Milone, M., Rastogi, R.K., del Sorbo, F. et al. Influence of cyproterone acetate on the activity ofβ-glucuronidase in the hypothalamus and cerebral cortex of the male mouse. Experientia 37, 1115–1116 (1981). https://doi.org/10.1007/BF02085044

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  • DOI: https://doi.org/10.1007/BF02085044

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