, Volume 37, Issue 10, pp 1109–1110 | Cite as

Massive transfusions with a plasma protein fraction: Effects on rat behavior

  • G. E. Esgandarian
  • J. S. Surinchak
  • P. A. O'Mara


The behavioral effects of a plasma protein fraction used as a plasma expander were determined in rats at various blood replacement levels. Results of operant conditioning tests indicated that significant treatment effects occurred on the first 3 days following transfusion. Initial decrements in performance were directly related to the lowered hematocrit levels following transfusion.


Treatment Effect Plasma Protein Behavioral Effect Protein Fraction Significant Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 2.
    A.M. Davison, Clin. Haemat.5, 135 (1971).Google Scholar
  2. 3.
    I.L. Woolf, P. Pappas, R.B. Pennell and B.M. Babior, Transfusion12, 125 (1972).Google Scholar
  3. 4.
    R.D. Woodson, B. Wranne and J.C. Detter, J. clin. Invest.52, 2717 (1973).Google Scholar
  4. 5.
    B. Ekblom, A.N. Goldbarg and B. Gullbring, J. appl. Physiol.33, 175 (1972).Google Scholar
  5. 6.
    F.A. Oski, B.E. Marshall, P.J. Cohen, H.J. Sugarman and L.V. Miller, Ann. intern. Med.74, 44 (1971).Google Scholar
  6. 7.
    F. DeVenuto, W.Y. Moores, A.I. Zegna and T.F. Zuck, Transfusion17, 555 (1977).Google Scholar

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • G. E. Esgandarian
    • 1
  • J. S. Surinchak
    • 1
  • P. A. O'Mara
    • 1
  1. 1.Division of BiorheologyLetterman Army Institute of ResearchSan FranciscoUSA

Personalised recommendations