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The causes of male infertility in 504 consecutive Nigerian patients

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Abstract

The causes of infertility in 504 men were studied prospectively. The major causes were varicocele (28.8%), infection (20.8%), bilateral testicular failure (15%), idiopathic oligospermia (6.6%), multifactorial (5.6%), cryptorchidism (4%), sexual problems (3.8%) and surgical injury (1.6%). Unilateral testicular torsion and sickle cell disease though of less frequent occurrence were of particular interest because their roles are only now beginning to be realized. Gonadotrophin deficiency was an insignificant cause of subfertility.

In spite of the high incidence of infection and past history of urethritisNeisseria gonorrheae was surprisingly not isolated from any patient.

Compared with Caucasian studies, the high incidence of infection, and the low incidence of gonadotrophin deficiency are major points of difference.

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References

  1. Dubin, L., Amelar, R. D.: Etiologic factors in 1294 consecutive cases of male infertility.Fertil. Steril., 22, 469 (1971).

    PubMed  Google Scholar 

  2. Ntia, U. P., Kufeji, L. I. D., Amaku, E. O.: The investigation of male infertility.Nig. Med. Jour., 5, 322 (1979).

    Google Scholar 

  3. Chukwudebelu, W. O., Esege, N., Megafu, U.: Aetiological factors in infertility in Enugu, Nigeria.Infertility, 2, 193 (1979).

    PubMed  Google Scholar 

  4. Macleod, J.: Seminal cytology in the presence of varicocele.Fertil. Steril., 16, 735 (1965).

    PubMed  Google Scholar 

  5. Agger, P.: Scrotal and testicular temperature: Its relation to sperm count before and after operation for varicocele.Fertil. Steril., 22, 286 (1971).

    PubMed  Google Scholar 

  6. Zorgniotti, A. W., Macleod, J.: Studies in temperature and human semen quality and varicocele.Fertil. Steril., 24, 854 (1979).

    Google Scholar 

  7. Glezerman, M., Rakowszky, M., Lunenfeld, B., Beer, R. Goldman, B.: Varicocele in oligospermic patients: pathophysiology and result after ligation and division of the internal spermatic vein.J. Urol., 115, 562 (1976).

    PubMed  Google Scholar 

  8. Cohen, M. S., Plaine, L., Brown, J. S.: The role of internal spermatic vein plasma catecholamine determination in subfertile men with varicocele.Fertil. Steril., 26, 1243 (1975).

    PubMed  Google Scholar 

  9. Rodniguez-Rigau, L. J., Weiss, D. B., Zukerman, Z., Grotjan, H. E., Smith, K. D., Steinberger, E.: A possible mechanism for the detrimental effect of varicocele in testicular function in man.Fertil. Steril., 30, 577 (1978).

    PubMed  Google Scholar 

  10. Russel, J. K.: Varicocele, age and infertility.Lancet, II, 222 (1957).

    Google Scholar 

  11. Macleod, J.: Further observations on the role of varicocele in human infertility.Fertil. Steril., 20, 608 (1969).

    Google Scholar 

  12. Stewart, B. H.: Varicocele in infertility: incidence and results of surgical therapy.J. Urol., 112, 222 (1974).

    PubMed  Google Scholar 

  13. Van Zyl, J. A., Menkveld, R., Kotze, J. T., Van, W., Retief, A. E., Van Niekerk, W. A.: Oligospermia: a seven-year survey of the incidence, chromosomal aberration, treatment and pregnancy rate.Int. J. Fertil., 20, 129 (1975).

    PubMed  Google Scholar 

  14. Comhaire, F., Monteyne, R., Kunnen, M.: The value of scrotal thermography as compared with selective retrograde venography of the internal spermatic vein for the diagnosis of “subclinical” varicocele.Fertil. Steril., 27, 694 (1976).

    PubMed  Google Scholar 

  15. Dubin, L., Amelar, R. D.: Varicocele size and results of varicocelectomy in selected subfertile men with varicocele.Fertil. Steril., 21, 8 (1970).

    Google Scholar 

  16. Dubin, L., Amelar, R. D.: Varicocelectomy as therapy in male infertility. A study of 504 cases.Fertil. Steril., 26, 217 (1975).

    PubMed  Google Scholar 

  17. Hanley, H. G., Harrison, R. G.: Nature and surgical treatment of varicocele.Br. J. Surg., 50, 64 (1962).

    PubMed  Google Scholar 

  18. Hommenal, T. Z., Sasson, S., Paz, G., Kraicer, P. F.: Improvement of fertility and semen quality in men treated with a combination of anticongestive and antibiotic drugs.Int. J. Fertil., 20, 45 (1975).

    PubMed  Google Scholar 

  19. Attila, T., Lesser, M. L.: Asymptomatic bacteriospermia in fertile and infertile men.Fertil. Steril., 36, 88 (1981).

    PubMed  Google Scholar 

  20. Quesada, E. M., Dukes, C. D., Deen, G. H., Franklin, R. R.: Genital infection and sperm agglutinating antibodies in infertile men.J. Urol., 99, 106 (1968).

    PubMed  Google Scholar 

  21. Caldamone, A. A., Cockett, A. T. K.: Infertility and genitourinary infection.Urology, 12, 305 (1978).

    Google Scholar 

  22. Dahlberg, B.: Asymptomatic bacteriospermia.Urology, 8, 563 (1976).

    PubMed  Google Scholar 

  23. Sokol, S., Jacobson, C. B., Derrick, F. C.: Use of methenamine hippurate in male infertility.Urology, 6, 59 (1975).

    PubMed  Google Scholar 

  24. Getzoff, P. L.: Surgical management of male infertility: Results of a survey.Fertil. Steril., 24, 553 (1973).

    PubMed  Google Scholar 

  25. Engle, E. T.: Atypical cytology in testis biopsies.J. Urol., 62, 694 (1949).

    PubMed  Google Scholar 

  26. Ward, B., Hunter, W. M.: The absent testicle: A report on a survey carried out amongst school boys in Nottingham.Br. Med. J., I, 1110 (1960).

    Google Scholar 

  27. Giarola, A.: Protection of reproductive capacity as a factor in therapy for undescended testicle.Fertil. Steril., 18, 375 (1967).

    PubMed  Google Scholar 

  28. Britton, B. J.: Spermatogenesis following bilateral orchidopexy in adult life.Br. J. Urol., 47, 464 (1975).

    PubMed  Google Scholar 

  29. Comhaire, F., Derom, F., Vermeulen, L.: The recovery of spermatogenesis in an azoospermic patient after operation for bilateral undescended testes at the age of 25 years.Int. J. Androl., I, 117 (1978).

    Google Scholar 

  30. Silber, S. J.: Recovery of spermatogenesis after testicle autotransplantation.Fertil. Steril., 37, 321 (1982).

    Google Scholar 

  31. Albescu, J. Z., Bergada, C., Cullen, M.: Male fertility in patients treated for cryptorchidism before puberty.Fertil. Steril., 22, 829 (1971).

    PubMed  Google Scholar 

  32. Hotchkiss, R. S., Pinto, A. B., Kleegman, S. J.: Artificial insemination with semen recovered from bladder.Fertil. Steril., 6, 37 (1955).

    Google Scholar 

  33. Segal, S., Polishuk, W. Z., Ben-David M.: Hyperprolactinemic male infertility.Fertil. Steril., 27, 1425 (1976).

    PubMed  Google Scholar 

  34. Hargreave, T. B., Kyle, K. F., Kelly, A. M., England, P.: Prolactin and gonadotrophins in 208 men presenting with infertility.Br. J. Urol., 49, 747 (1977).

    PubMed  Google Scholar 

  35. Suominen, J. J. O., Nikkanen, V., Multamaki, S., Hyyppa, M.: Prolactin in azoospermic men and its relation to testicular morphology, serum testosterone and gonadotrophin levels.Andrology, II (1), 15 (1979).

    Google Scholar 

  36. Pepperell, R. G.: Prolactin and reproduction.Fertil. Steril., 35, 267 (1981).

    PubMed  Google Scholar 

  37. Krarup, T.: The testes after torsion.Br. J. Urol. 60, 43 (1977).

    Google Scholar 

  38. Laurenti, C., Fagioli, A.: Antisperm antibodies in a case of secondary unilateral testicular atrophy.Br. J. Urol., 50, 352 (1978).

    PubMed  Google Scholar 

  39. Bartsch, G., Frank, S. T., Marberger, H., Miluz, G.: Testicular torsion: late results with special regard to fertility and endocrine function.J. Urol., 124, 375 (1980).

    PubMed  Google Scholar 

  40. Chakroborty, J., Jhunjhunwala, J.: Experimental unilateral torsion of the spermatic cord in guinea pigs.J. Androl., 3, 117 (1982).

    Google Scholar 

  41. Harrison, R. G., Moreno De Marval, M. J., Lewis-Jones, D. I., Connolly, R. C.: Mechanism of damage to the contralateral testis in rats with an ischaemic testis.Lancet, ii, 723 (1981).

    Google Scholar 

  42. Wyburn-Mason, R.: Sympathetic orchiopathia.Lancet, ii, 1417 (1981).

    Google Scholar 

  43. Kaya, M., Harrison, R. G.: An analysis of the effect of ischaemia on testicular ultrastructure.J. Pathol., 117, 105 (1975).

    PubMed  Google Scholar 

  44. Wallace, D. M. A., Gunter, P. A., Landon, G. V., Pugh, R. C. B., Hendry, W. F.: Sympathetic orchiopathia. An experimental and clinical study.Br. J. Urol., 54, 764 (1982).

    Google Scholar 

  45. Osegbe, D. N., Akinyanju, O. O., Amaku, E. O.: Fertility in males with sickle cell diseases.Lancet, ii, 275 (1981).

    Google Scholar 

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Osegbe, D.N., Amaku, E.O. The causes of male infertility in 504 consecutive Nigerian patients. International Urology and Nephrology 17, 349–358 (1985). https://doi.org/10.1007/BF02083505

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