International Urology and Nephrology

, Volume 16, Issue 2, pp 157–164 | Cite as

A contribution to the treatment of non-seminomatous testicular tumours

  • J. Baše
  • P. Navrátil
Article

Abstract

Experiences obtained in the treatment of non-seminomas in 86 men are evaluated. In 71 patients retroperitoneal lymphadenectomy was performed, in 15 also nephrectomy; in 84 men chemotherapy was used. The initial combination consisted of Vincristin, Bleomycin and cis-platin, the maintenance chemotherapy of Vincristin, Methotrexate and Leukeran (chlorambucil). Maintenance chemotherapy was also used in clinical stage N 0 M 0 and in 31 men at this stage no relapse occurred.

Keywords

Public Health Methotrexate Clinical Stage Bleomycin Chlorambucil 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Baše, J., Navrátil, P., Heger, L., Hlava, A.: A contribution of computed tomography in dissolution of operability of metastases of malignant tumours of the testis.R. Chir., 54, 823 (1980).Google Scholar
  2. 2.
    Behrendt, H., Brehmer, B.,Hossfeld, D. K.: Der diagnostische und therapeutische Stellenwert der “Second look operation” bei Patienten mit malignen Hodentumoren.Urologe [A],20, 231 (1981).PubMedGoogle Scholar
  3. 3.
    Donohue, J. P., Perez, J. M., Einhorn, L. H.: Improved management of non-seminomatous testis tumors.J. Urol., 122, 425(1979).Google Scholar
  4. 4.
    Donohue, J. P., Einhorn, L. H., Williams, S. D.: Cytoreductive surgery for metastatic testis cancer. Considerations of timing and extent.J. Urol., 123, 876 (1980).PubMedGoogle Scholar
  5. 5.
    Donohue, J. P., Zachary, J. M.,Maynard, B. R.: Distribution of nodal metastases in nonseminomatous testis cancer.J. Urol., 128, 315 (1982).PubMedGoogle Scholar
  6. 6.
    Einhorn, L. H.: Combination therapy with cis-dichlordiamineplatinum II in disseminated testicular cancer.Cancer Treat. Rep., 63, 1659 (1979).PubMedGoogle Scholar
  7. 7.
    Einhorn, L. H., Williams, S. D.: Chemotherapy of disseminated testicular cancer. A random prospective study.Cancer, 46, 1339 (1980).PubMedGoogle Scholar
  8. 8.
    Ekman, E. P., Edsmyr, F.: Chemotherapy of non-seminomatous testicular tumours —Stage I.Br. J. Urol., 53, 184 (1981).PubMedGoogle Scholar
  9. 9.
    Freitag, J., Freitag, G., Müller, G. W., Buhtz, C., Buhtz, P.: Ergebnisse computertomographischer und lymphographischer Diagnostik bei malignen Hodentumoren.Z. Urol. Nephrol., 75, 829 (1982).PubMedGoogle Scholar
  10. 10.
    Gothlin, J. H., Hoien, L.: Percutaneous transperitoneal fine needle biopsy of normal looking lymph nodes and small lesions at lymphography.Urol. Radiol., 1, 237 (1980).Google Scholar
  11. 11.
    Hendry, W. F., Barrett, A., McElwain, T. J., Wallace, D. M., Peckham, M. J.: The role of surgery in the combined management of metastases from malignant teratoma of testis.Br. J. Urol., 52, 38 (1980).PubMedGoogle Scholar
  12. 12.
    Hendry, W. F., Goldstraw, P., Husband, J. E., Barrett, A., McElwain, T. J., Peckham, M. J.: Elective delayed excision of bulky paraaortic lymph node metastases in advanced non-seminoma germ cell tumours of testis.Br. J. Urol., 53, 648 (1981).PubMedGoogle Scholar
  13. 13.
    Hoffkau, K., Tringelhoff, J., Sieber, S., Schmidt, C. G.: Actinomycin-D-Monotherapie bei malignen Hodentumoren.Urologe [A],15, 61 (1976).PubMedGoogle Scholar
  14. 14.
    Husband, J. E., Barrett, A., Peckham, M. J.: Evaluation of computed tomography in the management of testicular teratoma.Br. J. Urol., 53, 179 (1981).PubMedGoogle Scholar
  15. 15.
    Jaeger, U., Weissbach, L., Hartlapp, J. H., Vahlensieck, W.: Primäre Chemotherapie und nachfolgende Lymphadenektomie bei fortgeschrittener Metastasierung von Hodentumoren.Aktuel. Urol., 12, 26 (1981).Google Scholar
  16. 16.
    Pearse, H. D., Fuchs, E. F.: Adjuvant chemotherapy with Vinblastin and Bleomycin in stage B non-seminomatous germ cell tumours of the testis.J. Urol., 128, 712 (1982).PubMedGoogle Scholar
  17. 17.
    Pontes, J. E., Mogois, I., Staubitz, W., Murphy, G. P.: The treatment of stage I and II non-seminomatous testicular tumours: The Buffalo experience from 1970 to 1979.J. Urol., 128, 1201 (1982).PubMedGoogle Scholar
  18. 18.
    Samuels, M. L., Johnson, D. E.: Adjuvant therapy of testis cancer: The role of Vinblastin and Bleomycin.J. Urol., 124, 369 (1980).PubMedGoogle Scholar
  19. 19.
    Scardino, P. T.: Adjuvant chemotherapy is of value following retroperitoneal lymph node dissection for non-seminomatous testicular tumours.Urol. Clin. North Am., 7, 735 (1980).PubMedGoogle Scholar
  20. 20.
    Skinner, D. G., Scardino, P. T.: Relevance of biochemical tumour markers and lymphadenectomy in management of non-seminomatous testis tumours. Current prospective.J. Urol., 123, 378 (1980).PubMedGoogle Scholar
  21. 21.
    Skinner, D. G.: Advanced metastatic testicular cancer: The need for reporting results according to initial extent of disease.J. Urol., 128, 312 (1982).PubMedGoogle Scholar
  22. 22.
    Vogler, H., Altmann, R., Schmidt, W., Kunern, K. F., Sieger, W.: Stellenwert der Lymphographie, Kavographie, Sonographie und Computer-Tomographie bei der Stadieneinteilung und Verlaufskontrolle germinaler Hodentumoren.Z. Urol. Nephrol., 75, 723 (1982).PubMedGoogle Scholar
  23. 23.
    Vugrin, D., Whitmore, W. F., Golbey, R. B.: Vinblastin, Actinomycin D, Bleomycin, Cyclophosphamide and cis-Platin combination chemotherapy in metastatic testis cancer.J. Urol., 128, 1205 (1982).PubMedGoogle Scholar
  24. 24.
    Vugrin, D., Whitmore, W. F., Herr, H., Sogani, P., Golbey, R. B.: Adjuvant Vinblastin, Actinomycin D, Bleomycin, Cyclophosphamide and cis-platinum chemotherapy regimen with and without maintenance in patients with stage II B testis cancer.J. Urol., 128, 715 (1982).PubMedGoogle Scholar
  25. 25.
    Wajsman, Z., Gammara, M., Park, J. J., Beckley, S., Pontie, J. J.: Transabdominal fine needle aspiration of retroperitoneal lymph nodes in staging of genitourinary tract cancer. (Correlation with lymphography and lymph node dissection findings.)J. Urol., 128, 1238 (1982).PubMedGoogle Scholar
  26. 26.
    Weissbach, L., Neoliter, D., Janson, R., Vahlensieck, W.: Limitiert die retroperitoneale Gefässäste die Operabilität des metastasierenden Hodentumors?Urologe [A]21, 211 (1982).PubMedGoogle Scholar
  27. 27.
    Wettlaufer, J. N.: Germinal testis tumours: Aggressive approach.J. Urol., 117, 593 (1976).Google Scholar

Copyright information

© Akadémiai Kiadó 1984

Authors and Affiliations

  • J. Baše
    • 1
  • P. Navrátil
    • 1
  1. 1.Department of UrologyCharles University Medical School at Hradec KrálovéCzechoslovakia

Personalised recommendations