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The influence of the H-2 receptor antagonist ranitidine on cadaver kidney allograft function

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Abstract

To assess the influence of ranitidine on kidney allograft function a doubleblind, placebo-controlled clinical study in 42 cadaver kidney recipients has been performed. Patients received ranitidine or placebo for 1 month. Four years after transplantation 81% of the patients in the control group were alive; 67% in the control and 71% in the ranitidine group with functioning grafts. These differences were statistically not significant. However, a slightly more intensive steroid therapy was given to keep the ranitidine patients adequately immunosuppressed. Ranitidine thus can be safely used in kidney graft recipients. Because of a lack of gastrointestinal complications in both groups, no conclusions can be drawn regarding the prophylactic value of ranitidine.

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Authors and Affiliations

  1. The Transplantation Institute, Warsaw Medical School, Warsaw, Poland

    T. Orłowski & M. Smogorzewski

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  1. T. Orłowski
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  2. M. Smogorzewski
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This work was supported by grant 10-MZ-XIII from the Ministry of Health.

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Orłowski, T., Smogorzewski, M. The influence of the H-2 receptor antagonist ranitidine on cadaver kidney allograft function. International Urology and Nephrology 18, 205–210 (1986). https://doi.org/10.1007/BF02082609

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  • DOI: https://doi.org/10.1007/BF02082609

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