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Zinc in patients with chronic renal failure

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Abstract

In order to assess zinc status in patients with chronic renal failure (CRF) plasma and erythrocyte zinc levels were determined in 13 patients undergoing regular haemodialysis. Additional determinations of plasma copper, plasma and erythrocyte magnesium and potassium were also performed. The mean plasma zinc level was slightly less than normal, but the difference was not statistically significant. The erythrocyte zinc content, however, as well as erythrocyte magnesium and potassium levels were significantly increased (p<0.001). This increase may be partly related to haemolysis in uraemia. Plasma copper concentration in CRF patients did not differ significantly from the control level. The almost normal plasma zinc concentration, elevated erythrocyte zinc, and normocupraemia do not indicate zinc deficiency in CRF patients.

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References

  1. Antoniou, L. D., Shalhoub, R. J., Schechter, G. P.: The effect of zinc on cellular immunity in chronic uremia.Am. J. Clin. Nutr., 34, 1912 (1981).

    PubMed  Google Scholar 

  2. Antoniou L. D., Shalhoub, R. J., Sudhakar, T., Smith, J. C. Jr.: Reversal of uraemic impotence by zinc.Lancet, 2, 895 (1977).

    PubMed  Google Scholar 

  3. Atkin-Thor, E., Goddard, B. W., O'Nion, J., Stephen, R. L., Kolff, W. J.: Hypogeusia and zinc depletion in chronic dialysis patients.Am. J. Clin. Nutr., 31, 1948 (1978).

    PubMed  Google Scholar 

  4. Blendis, L. M., Ampil, M., Wilson, D. R., Kiwan, J., Labranche, J., Johnson, M., Williams, C.: The importance of dietary protein in the zinc deficiency of uremia.Am. J. Clin. Nutr., 34, 2658 (1981).

    PubMed  Google Scholar 

  5. Blomfield, J., McPherson, J., George, C. R. P.: Active uptake of copper and zinc during haemodialysis.Br. Med. J., 2, 141 (1969).

    Google Scholar 

  6. Burns, R. R., Fell, G. S.: Estimation and interpretation of plasma zinc fractions.Scott. Med. J., 21, 153 (1976).

    PubMed  Google Scholar 

  7. Condon, C. J., Freeman, R. M.: Zinc metabolism in renal failure.Ann. Intern. Med., 73, 531 (1970).

    PubMed  Google Scholar 

  8. Desforges, J. F., Dawson, J. P.: The anemia of renal failure.Arch. Intern. Med., 101, 326 (1958).

    Google Scholar 

  9. Golden, M. H. N., Golden, B. E.: Trace elements Potential importance in human nutrition with particular reference to zinc and vanadium.Br. Med. Bull., 37, 31 (1981).

    PubMed  Google Scholar 

  10. Gonella, M., Bartolini, V., Buzzigoli, G., Betti, G.: The relationship between Ht and erythrocyte potassium concentration in patients on regular hemodialysis.Nephron, 25, 184 (1980).

    PubMed  Google Scholar 

  11. Gonella, M., Betti, G., Buzzigoli, G., Bartolini, V.: The relationship between hematocrit and erythrocyte magnesium concentration in patients on regular dialysis.Nephron, 24, 134 (1979).

    PubMed  Google Scholar 

  12. Gordon, E. F., Gordon, R. C., Passal, D. B.: Zinc metabolism: basic, clinical, and behavioral aspects.J. Pediatr., 99, 341 (1981).

    PubMed  Google Scholar 

  13. Guillard, O., Biais-Sauvetre, M. H., Reiss, D., Gombert J.: Physiologie et pathologie du zinc. Données recentes.Pathol. Biol. (Paris),28, 469 (1980).

    PubMed  Google Scholar 

  14. Hurley, L. S., Tao, S.: Alleviation of teratogenic effects of zinc deficiency by simultaneous lack of calcium.Am. J. Physiol., 222, 322 (1972).

    PubMed  Google Scholar 

  15. Kirchgesner, M., Reichlmayr-Lais, A. M., Schwartz, F. J.: Interactions of trace elements in human metabolism. XIIth International Congress of Nutrition, August 16–21, 1981. Alan R. Liss, Inc., New York 1981, p. 189.

    Google Scholar 

  16. Mahayan, S. K., Prasad, A. S., Rabbani, P., Briggs, N. A., McDonald, F. D.: Zinc metabolism in uremia.J. Lab. Clin. Med., 94, 693 (1979).

    PubMed  Google Scholar 

  17. Mahler, D. J., Walsh, J. R., Haynie, G. D.: Magnesium, zinc, and copper in dialysis patients.Am. J. Clin. Pathol., 56, 17 (1971).

    PubMed  Google Scholar 

  18. Mansouri, K., Halsted, J., Gombas, E. A.: Zinc, copper, magnesium and calcium in dialyzed and non-dialyzed uremic patients.Arch. Intern. Med., 125, 88 (1970).

    PubMed  Google Scholar 

  19. Prasad, A. S.: Trace Elements and Iron in Human Metabolism. Plenum Medical Book Company, New York 1978.

    Google Scholar 

  20. Rose, G. A., Willden, E. G.: Whole blood, red cell, and plasma total and ultrafilterable zinc levels in normal subjects and in patients with chronic renal failure with and without hemodialysis.Br. J. Urol., 44, 281 (1972).

    PubMed  Google Scholar 

  21. Shaw, A. B.: Haemolysis in chronic renal failure.Br. Med. J., 2, 213 (1967).

    PubMed  Google Scholar 

  22. Siegler, R. L., Eggert, J. V., Udomkesmalee, E.: Diagnostic indices of zinc deficiency in children with renal diseases.Ann. Clin. Lab. Sci. 11, 428 (1981).

    PubMed  Google Scholar 

  23. Tsukamoto, Y., Iwanami, S., Marumo, F.: Disturbances of trace element concentrations in plasma of patients with chronic renal failure.Nephron, 26, 174 (1980).

    PubMed  Google Scholar 

  24. Vreman, H. J., Venter, Ch., Leegwater, J., Oliver, C., Weiner, M. W.: Taste, smell and zinc metabolism in patients with chronic renal failure.Nephron, 26, 163 (1980).

    PubMed  Google Scholar 

  25. Wacker, W. E. C., Williams, R. J.: Magnesium/calcium balances and steady states of biological systems.J. Theor. Biol. 20, 65 (1968).

    PubMed  Google Scholar 

  26. Zetin, M., Stone, R. A.: Effects of zinc in chronic hemodialysis.Clin. Nephrol., 13, 20 (1980).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. First Medical Clinic, Clinical Laboratory, Centre of Postgraduate Medical Education, Warszawa, Poland

    W. Piechota, T. Dobrucki, N. Symonowicz, Elzbieta Wadowska & Ewa Murkowska

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  1. W. Piechota
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  2. T. Dobrucki
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  3. N. Symonowicz
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  4. Elzbieta Wadowska
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  5. Ewa Murkowska
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Piechota, W., Dobrucki, T., Symonowicz, N. et al. Zinc in patients with chronic renal failure. International Urology and Nephrology 15, 377–382 (1983). https://doi.org/10.1007/BF02082558

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  • DOI: https://doi.org/10.1007/BF02082558

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