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Detecting mitomycin C in human plasma during intravesical therapy

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Abstract

Mitomycin C (MMC) concentrations in plasma and urine were measured in five patients with intact bladder during intravesical instillation therapy. No MMC was detected in plasma by a selective high performance liquid chromatographic (HPLC) method. The detection limit of the method is 1 ng/ml. Our results are in accordance with clinical experiences of the lack of systemic toxicity during MMC instillation therapy. There was a remarkable loss of MMC in the voided urine. The probable explanation could be that a considerable amount of MMC is absorbed into the bladder wall.

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  1. Urological Unit, Second Department of Surgery, Helsinki, Finland

    K. Jauhiainen

  2. University Central Hospital, Helsinki, Finland

    K. Jauhiainen

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  1. K. Jauhiainen
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Jauhiainen, K. Detecting mitomycin C in human plasma during intravesical therapy. International Urology and Nephrology 17, 155–158 (1985). https://doi.org/10.1007/BF02082487

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  • DOI: https://doi.org/10.1007/BF02082487

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