International Urology and Nephrology

, Volume 12, Issue 4, pp 367–374 | Cite as

The effect of uraemic “middle-sized molecules” on T lymphocyte functions

  • K. Kálmán
  • L. Lőcsey
  • M. Hauck
  • A. Leövey


The activity of the leucocyte inhibitory factor (LIF) stimulated with Concanavalin A was examined in chronic uraemic, haemodialysed patients. It was found that the LIF activity decreased in chronic uraemic patients as compared with the normal controls.

The absolute T lymphocyte count and active E rosette formation also decreased. Inin vitro experiments the authors have also examined the inhibitory effect of the socalled “middle-sized molecule” (MSM) on uraemic materials separated from the serum and the haemofiltrate. They observed that the materials with a molecular weight of 1000–1500 isolated both from the serum and the haemofiltrate significantly inhibited the Con A stimulated LIF production of normal lymphocytes and decreased the ratio of the active E rosette-forming T lymphocytes.

On the basis of their exeeriments the MSM uraemic materials are considered responsible for the decreased immune reactivity of uraemic patients. These uraemic toxins can be dialysed.


Public Health Molecular Weight Immune Reactivity Normal Control Inhibitory Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Akadämiai Kiadó 1980

Authors and Affiliations

  • K. Kálmán
    • 1
  • L. Lőcsey
    • 1
  • M. Hauck
    • 1
  • A. Leövey
    • 1
  1. 1.First Department of Medicine and Institute of BiochemistryUniversity Medical SchoolDebrecen

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