Abstract
In 115 patients with various glomerular diseases and in 23 with chronic pyelonephritis the comparative incidence of glomerular fibrin deposits, and blood and urinary FDP was studied for evaluation of their clinical value. The results of the study indicate that the determination of urinary FDP is the most reliable clinico-laboratory test for the presence of increased intrarenal haemocoagulation. Moreover, the quantitative assessment of urinary FDP could be also used as an index for estimating the activity of the pathological process, the selectivity of proteinuria, the need for anticoagulant therapy, and the prognosis of the disease.
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Belitzkaya, F. A.: Clinical value of the determination of fibrin and fibrinogen degradation products in the urine in patients with glomerulonephritis (in Russian).Ter. Arch., 4, 46 (1975).
Bind, R. E.: Fibrinolytic split products.Arch. Intern. Med., 137, 182 (1973).
Blainey, J. D., Terry, J. M.: Urinary fibrinogen degradation products and differential protein clearance in renal disease.Clin. Nephrol., 11, 140 (1979).
Drannik, G. N.: Mechanisms of formation and diagnostic value of fibrin/fibrinogen degradation products in kidney allotransplantation.Urol. Nephrol., 2, 62 (1979).
George, C. R. P.: Akinetic evaluation of hemostasis in renal disease.New Engl. J. Med., 291, 1111 (1974).
Hall, C. L.: Urinary fibrin/fibrinogen degradation products in nephrotic syndrome.Brit. Med. J., 1, 419 (1975).
Nagai, T., Kawai, C.: Fibrinogen and FDP-E antigen deposits in nephritic kidneys.Nephron, 21, 16 (1978).
Naisch, P.: Urinary fibrinogen derivative excretion and intraglomerular fibrin deposition in glomerulonephritis.Brit. Med. J., 1, 544 (1974).
Shapkin, E. I.: Immunoglobulins and fibrin degradation products in patients with glomerulonephritis and pyelonephritis (in Russian). In:Aktualnye voprossi nefrologii. Moscow, 1977, pp. 146–150.
Sokratov, N. B., Sofronova, T. A.: Hemocoagulation disturbances in glomerulonephritis (in Russian).Urol. Nephrol., 1, 64 (1979).
Tareeva, I. E.: Significance of the determination of fibrin degradation products in the blood plasma and urine in renal patients. In:Aktualnye voprossi nefrologii. Moscow, 1977, pp. 140–146.
Tishkov, Iv.: Diagnostic value of fibrin/fibrinogen degradation products in some renal diseases (in Bulgarian). Symposium on Laboratory Diagnostics of Hepatic and Renal Diseases, Plovdiv, 1978.
Vanrenterghen v., V.: Glomerulonephritis. Symposium, Cottbus, 21–23 May, 1980.
Withworth, J.: Urinary fibrin-degradation products and the site of urinary infection.Lancet, 1, 234 (1973).
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Tishkov, I., Tschoukanov, C., Doytshinov, D. et al. Fibrin deposits in the glomeruli and fibrin/fibrinogen degradation products (FDP) in the blood and urine in some renal diseases. International Urology and Nephrology 14, 89–93 (1982). https://doi.org/10.1007/BF02082388
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DOI: https://doi.org/10.1007/BF02082388