Abstract
A study was carried out to verify the clinical usefulness of the elaborated method for the measurement of antistreptococcal antibody in revealing the streptococcal etiology of glomerulonephritis.
In 158 patients with glomerulonephritis antistreptococcal antibody (ASA), circulating immune complexes (CIC) and haemolytic activity of the complement were measured.
On the basis of immune complex formation it has been concluded that streptococcal infection may cause glomerulonephritis. Serial determinations of ASA and CIC are helpful in establishing the streptococcal etiology of glomerulonephritis and in monitoring the course of the disease.
Similar content being viewed by others
References
Albini, B., Brentjens, J. R., Andres, G. A.: The immunopathology of the kidney. In: J. Turk (ed.): Current Topics in Immunology, No. 11. E. Arnold 1979.
Baldwin, D. S., Gluck, M. C., Schacht, R. G., Gallo, G. R.: The long-term course of poststreptococcal glomerulonephritis.Ann. Intern. Med., 80, 342 (1974).
Border, W. A.: Immune complex detection in glomerular diseases.Nephron, 24, 105 (1979).
Couser, W. G., Salant, D. J.: In situ immune complex formation and glomerular injury.Kidney Int., 17, 1 (1980).
Creighton, W. D., Lambert, P. H., Miescher, P. A.: Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol.J. Immunol., 111, 1219 (1973).
Fleuren, G., Grond, J., Hoedemaeker, P. J.: In situ formation of subepithelial glomerular immune complexes in passive serum sickness.Kidney Int., 17, 631 (1980).
Germuth, F. G., Rodriquez, E.: Immunopathology of the renal glomerulus. Immune complex deposit and antibasement membrane disease. Little Brown and Co., Boston 1973.
Golbus, S. M., Wilson, C. B.: Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall.Kidney Int., 16, 148 (1979).
Halbert, S. P.: Analysis of human streptococcal infections by immunodiffusion studies of the antibody response. In: J. W. Uhr (ed.): The Streptococcus, Rheumatic Fever and Glomerulonephritis. The Williams and Wilkins Co., Baltimore 1964, p. 83.
Krzymański, M., Möller, E., Bergström, J.: Cell-mediated and humoral immunity to streptococcal cell wall antigenic extract in patients with glomerulonephritis and in healthy controls.Scand. J. Immunol., 4, 295 (1975).
Krzymański, M., Szmeja, Z., Kulczyński, B., Pospieszyński, M., Bączyk, K.: Antistreptococcal cell wall antibodies (ScwA) in chronic tonsillitis (CT). Abstracts XIVth Congress E.D.T.A., Helsinki 1977, p. 282.
Krzymański, M., Michalska, E., Bączyk, K.: The use of radioimmunoassay for detection of circulating antistreptococcal antibody in patients with glomerulonephritis.Int. Urol. Nephrol. (in press).
lange, K., Ahmed, U., Kleinberger, H., Treser, G.: A hitherto unknown streptococcal antigen and its probable relation to acute poststreptococcal glomerulonephritis.Clin. Nephrol., 5, 207 (1976).
Mancini, G.: Immunochemical quantitation of antigen by single radial immunodiffusion.Immunochemistry, 2, 235 (1965).
Mayer, M. M.: Procedure for titration of complement. In: E. A. Kabat, M. M. Mayer (eds): Experimental Immunochemistry. 2nd ed. Ch. C. Thomas Publ., Springfield, Ill. 1961, p. 149.
Mohammed, L., Ausell, B. M., Halborow, E. J., Bryceson, A. D. M.: Circulating immune complexes in subacute infective endocarditis and poststreptococcal glomerulonephritis.J. Clin. Path., 30, 308 (1977).
Morito, T., Taninoto, K., Hashimoto, Y., Horiuchi, Y., Juji, T.: Fc-rosette inhibition by hypocomplementaemic systemic lupus erythematosus sera.Ann. Rheum. Dis., 35, 415 (1976).
Nielsen, H., Svehag, S. E.: Detection and differentiation of immune complexes and IgG aggregates by a complement consumption assay.Acta Path. Microbiol. Scand., 84, 261 (1976).
Ooi, Y. M., Vallota, E. H., West, C. D.: Serum immune complexes in membrano-proliferative and other glomerulonephritides.Kidney Int., 11, 275 (1977).
Richet, G., Fillastra,J. P., Morel-Maroger, L., Bariety, J.: Change from diffuse proliferative to membranous glomerulonephritis. Renal biopsies in four cases.Kidney Int., 5, 57 (1974).
Rossen, R. D., Reisberg, M. A., Singer, D. B., Schloender, E. X., Suki, W. N., Hill, L. L., Eknoyan, G.: Soluble immune complexes in sera of patients with nephritis.Kidney Int., 10, 256 (1976).
Saltzman, M., Ahmed, U., Grover, A. Klienberger, H., Sagel, I., Lange, K.: Endostreptosin antibody titers in renal diseases. Abstracts VIIth Int. Congr. Nephrol., Montreal 1978.
Villerreal, H. Jr., van de Rijn, I., Mahabir, R., Zabriskie, J. B.: An extracellular protein unique to “nephritogenic” streptococci. Abstracts VIIth Int. Congr. Nephrol., Montreal 1978.
Zabriskie, J. B., Lewshenia, R., Möller, G., Wahle, B., Falk, R. E.: Lymphocytic responses to streptococcal antigens in glomerulonephritic patients.Science, 168, 1105 (1970).
Zabriskie, J. B.: The role of streptococci in human glomerulonephritis.J. Exp. Med., 134, 180 (1971).
Zubler, R. H., Lambert, P. H.: Detection of immune complexes in human diseases.Prog. Allergy, 24, 1 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krzymański, M., Falkiewicz, K., Kopeć, W. et al. Humoral immunity to streptococcal antigen in acute and chronic glomerulonephritis. International Urology and Nephrology 14, 75–87 (1982). https://doi.org/10.1007/BF02082387
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02082387