International Urology and Nephrology

, Volume 8, Issue 1, pp 63–66 | Cite as

Piromidic acid and its ethylic ester: Absorption, distribution, excretion

  • S. Rosini
  • D. Benetti


The absorption, distribution and excretion of piromidic acid and its ethyl ester were investigated in the rat. When administered orally the ethyl ester was well absorbed and subsequently hydrolysed, giving much higher blood and tissue concentration than a corresponding dose of the parent compound. The antimicrobial activity of urine and bile samples was also investigated.


Public Health Ester Ethyl Antimicrobial Activity Ethyl Ester 
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  1. 1.
    Shimizu, M., Nakamura, S., Takase, Y.: Piromidic acid, a new antibacterial agent: antibacterial properties.Antimicrob. Ag. Chemother. 117 (1970).Google Scholar
  2. 2.
    Shimizu, M., Sekine, Y., Higuchi, H., Suzuki, H., Nakamura, S.: Piromidic acid, a new antibacterial agent.Antimicrob. Ag. Chemother. 123 (1970).Google Scholar
  3. 3.
    Kanazawa, K.: Piromidic acid. Antimicrobial activity, active levels and quantitative determination of separate active metabolite levels in body fluids.Nippon Kagaku Ryohogakukai Zasshi 19, 333 (1971).Google Scholar

Copyright information

© Akadémiai Kiadó 1976

Authors and Affiliations

  • S. Rosini
    • 1
  • D. Benetti
    • 1
  1. 1.Research LaboratoriesGentili InstitutePisaItaly

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