Advertisement

International Urology and Nephrology

, Volume 14, Issue 4, pp 333–347 | Cite as

Epidemiology, pathogenesis and diagnosis of calcium oxalate urolithiasis

  • E. W. Vahlensieck
  • D. Bach
  • A. Hesse
  • A. Strenge
Article

Abstract

In the German Federal Republic, the incidence of urolithiasis is 0.54% and the prevalence is 4%. Calcium oxalate stones are to be expected in over 60% of the cases. Pathogenetic factors are discussed. It is demonstrated that the overconsumption of chocolate, rhubarb and spinach brings about risk situations for stone formation, while asparagus and tomatoes present no risk. The increased animal protein and alcohol intake may be the most important reasons for the accumulations of calcium oxalate stones. Beside the minimum investigation programme it is demon trated by examples that recurrent stone formers need an extended investigation to find out more about the pathogenesis, in order to determine an effective treatment or to prevent recurrences.

Keywords

Public Health Calcium Alcohol Effective Treatment Oxalate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Asper, R.: Discussion remark.Fortschr. Urol. Nephrol., 14, 433 (1979).Google Scholar
  2. 2.
    Bastian, H.-P., Gebhardt, M. A. H.: Einige statistische Ergebnisse von 11,000 Harnsteinanalysen mittels Röntgendiffraktion. Harnsteinsymposium, Bonn 1981.Google Scholar
  3. 3.
    Butz, M.: Discussion remark.Fortschr. Urol. Nephrol., 14, 433 (1979).Google Scholar
  4. 4.
    Coe, F. L.: Calcium oxalate crystallisation initiated with monosodium urate.Clin. Res., 20, 589 (1972).Google Scholar
  5. 5.
    Costello, F.: The effect of ascorbic acid on oxalate metabolism. In: G. A. Rose, W. G. Robertson, R. W. E. Watts (eds): Oxalate in Human Biochemistry and Clinical Pathology. Proc. Oxalate Workshop, Wellcome Foundation, London 1979.Google Scholar
  6. 6.
    Hagmeier, V.: Discussion.Fortschr. Urol. Nephrol., 14, 433 (1979).Google Scholar
  7. 7.
    Hesse, A., Bach, D., Vahlensieck, W.: Epidemiologic survey on urolithiasis in the German Federal Republic. In.: G. Brockis, B. Finlayson (eds): Urinary Calculus. PSG Publ. Co., Littleton, Mass. 1981.Google Scholar
  8. 8.
    Ljunghall, S., Backman, U., Danielson, B. G., Johansson, G., Wikström, B.: Epidemiology of renal stones in Sweden. In: J. G. Brockis, B. Finlayson (eds): Urinary Calculus. PSG Publ. Co., Littleton, Mass. 1981.Google Scholar
  9. 9.
    Nancollas, G. H. (ed.): Biological Mineralisation and Demineralisation. Springer, Berlin-Heidelberg-New York 1982.Google Scholar
  10. 10.
    O'Regan, P. F. B., Constable, A. R., Harrison, A. R., Joekes, A. M., Kasidas, G. P., Rose, G. A.: The management of the primary hyperoxaluric patient. In: G. A. Rose, W. G. Robertson, R. W. E. Watts (eds): Oxalate in Human Biochemistry and Clinical Pathology. Proc. Oxalate Workshop, Wellcome Foundation, London 1979.Google Scholar
  11. 11.
    Pak, C. Y. C., Arnold, L. H.: Heterogeneous nucleation of calcium oxalate by seeds of monosodium urate.Proc. Soc. Exp. Biol. Med., 149, 930 (1975).PubMedGoogle Scholar
  12. 12.
    Robertson, W. G., Knowles, F., Peacock, M.: Urinary acid mucopolysaccharide inhibitors of calcium oxalate crystallisation. In: H. Fleisch, W. G. Robertson, L. H. Smith, W. Vahlensieck (eds): Urolithiasis Research. Plenum Press, New York-London 1976.Google Scholar
  13. 13.
    Robertson, W. G., Peacock, M., Heyburn, P. J., Marshall, R. W., Williams, R. E., Clark, P. B.: The significance of mild hyperoxaluria in calcium stone-formation. In: G. A. Rose, W. G. Robertson, R. W. E. Watts (eds): Oxalate in Human Biochemistry and Clinical Pathology. Proc. Oxalate Workshop, Wellcome Foundation, London 1979.Google Scholar
  14. 14.
    Robertson, W. G., Peacock, M., Quimet, D., Heyburn, P. J., Rutherford, A.: The main risk factor for calcium oxalate stone disease in man: Hypercalciuria or mild hyperoxaluria? In: L. H. Smith, W. G. Robertson, B. Finlayson (eds): Urolithiasis-Clinical and Basic Research. Plenum Press, New York-London 1981.Google Scholar
  15. 15.
    Scott, R., Mathieson, A., McLelland, A.: The reduction in stone recurrence and oxalate excretion by allopurinol. In: G. A. Rose, W. G. Robertson, R. W. E. Watts (eds): Oxalate in Human Biochemistry and Clinical Pathology. Proc. Oxalate Workshop, Wellcome Foundation, London 1979.Google Scholar
  16. 16.
    Scott, R., Freeland, R., Mowat, W., Paterson, P. J., Orr, P. S., Yates, A. J., Mills, E. A.: The prevalence of renal stones in a random population and a volunteer population. In: G. Brockis, B. Finlayson (eds): Urinary Calculus. PSG Publ. Co., Littleton, Mass. 1981.Google Scholar
  17. 17.
    Smith, L. H., Werness, P. G., Wilson, D. M.: Enteric hyperoxaluria: Associated metabolic abnormalities that promote renal calculi. In: Human Biochemistry and Clinical Pathology. Proc. Oxalate Workshop, Wellcome Foundation, London 1979.Google Scholar
  18. 18.
    Strenge, A.: Einfluss der Ernährung auf lithogene und inhibitorische Substanzen. Inaug. Diss., Bonn 1982.Google Scholar
  19. 19.
    Vahlensieck, W.: Einfluss der Ernährung auf lithogene Substanzen im Serum und Urin. Report XVIIIth Congr. Soc. Int. Urol., Vol. II, p. 72 Paris 1979.Google Scholar
  20. 20.
    Vahlensieck, W.: Allgemeine Kausal- und Formalgenese. In: W. Vahlensieck (ed.): Urolithiasis, Vol. 1. Springer, Berlin-Heidelberg-New York 1979.Google Scholar
  21. 21.
    Vahlensieck, W.: Epidemiologie und Pathogenese des Harnsteinleidens.Dtsch. Med. Wochenschr., 105, 799 (1980).PubMedGoogle Scholar
  22. 22.
    Vahlensick, W., Hesse, A., Bach, D.: Zur Prävalenz des Harnsteinleidens in der Bundesrepublik Deutschland.Urologe [B],20, 273 (1980).Google Scholar
  23. 23.
    Vahlensieck, W., Bach, D., Hesse, A., Schneeberger, W.: Metabolic investigation in 407 recurrent stone-formers and healthy controls on condition of individual as well as standard diet. In: L. H. Smith, W. G. Robertson, B. Finlayson: Urolithiasis. Plenum Press, New York-London 1981.Google Scholar
  24. 24.
    Vahlensieck, W., Hesse, A., Bach, D.: Inzidenz, Prävalenz und Mortalität des Harnsteinleidens in der Bundesrepublik Deutschland.Fortschr. Urol. Nephrol., 17, 1 (1982).Google Scholar
  25. 25.
    Ziegler, E.: Epidemiologie des Alkoholismus. In: R. Teschke, C. S. Lieber (eds): Alkohol und Organschäden, Witzstrock, Baden-Baden 1981, pp. 11–18.Google Scholar
  26. 26.
    Zollinger, H. U.: Nieren und ableitende Harnwege. In: W. Doerr, E. Uehlinger (eds): Spezielle pathologische Anatomie. Vol. 3. Springer, Berlin-Heidelberg-New York 1966.Google Scholar

Copyright information

© Akadémiai Kiadó 1982

Authors and Affiliations

  • E. W. Vahlensieck
    • 1
  • D. Bach
    • 1
  • A. Hesse
    • 1
  • A. Strenge
    • 1
  1. 1.Department of UrologyUniversity Hospital BonnFRG

Personalised recommendations