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Experimental pyelonephritis

Route of infection, course and immunological aspects

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Abstract

Pyelonephritis was induced in Wistar rats either by intravenous injection of E. coli after temporary occlusion of one ureter or by intravesical injection. The route of infection and course of the disease were controlled by histological, immunohistological and bacteriological studies. The following results were obtained.

  1. 1.

    Following both intravenous and intravesical bacterial inefction the kidney is infected via the blood stream. The bacteria reach the tubular lumen after passing through the glomerules, multiply there and penetrate from the tubular epithelium into the interstitial space. The urine carries them into the renal pelvis and they invade the renal interstitium by retrograde ascension.

  2. 2.

    In the chronic phase of pyelonephritis the antigen is localized in the big phagocytes of the inflammatory infiltrates, the cellular tubular casts, epithelium and connective tissue, especially in contracted kidneys.

  3. 3.

    In the chronic phase of pyelonephritis it is often impossible to detect bacteria. Since in such cases the bacterial antigen is found by immune-histological methods, the hypothesis of the further progression of pyelonephritis by antibody reactions against bacterial antigen in the kidney is supported.

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Authors and Affiliations

  1. 2nd Department of the Medical University and Polyclinic of Charité, Berlin, GDR

    Hoang Tuan, I. Hagemann, H. Briedigkeit & W. Dutz

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  1. Hoang Tuan
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  2. I. Hagemann
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  3. H. Briedigkeit
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  4. W. Dutz
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Tuan, H., Hagemann, I., Briedigkeit, H. et al. Experimental pyelonephritis. International Urology and Nephrology 4, 285–295 (1972). https://doi.org/10.1007/BF02081882

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