Abstract
Urosepsis due to nosocomial infection caused by multi-drug-resistant Klebsiella, Proteus and Pseudomonas strains is an increasingly important problem in Western Germany. It is a complication of any procedure involving the genitourinary tract, particularly common after TUR of the prostate. Its incidence increases with the socalled prophylactic use of antibiotics. Its dangers are connected with the frequent development of septicemic shock, the mortality of which is still very high. Since the underlying cause is often obscured by ineffective antibiotic therapy, it is recommended to take blood and urine for culture in all patients with sudden hypotension before the first dose of antibiotic is administered. A practical guide to initial therapy for undiagnosed bacteremia is presented. Particular emphasis is given to constant monitoring of c.v.p. and a careful search for a surgically treatable cause.
Similar content being viewed by others
References
Altemeier, W. A., Cole, W.: Nature and treatment of septic shock.Arch. Surg. 77, 498 (1958).
Altemeier, W. A., Todd, J. C., Inge, W. W.: Gram-negative septicemia: A graving threat.Ann. Surg. 166 530 (1967).
Brumfitt, W., Percival, A., Leigh, D. A.: Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea.Lancet I 1289, (1967).
Brumfitt, W., Leigh, D. A.: The incidence and bacteriology of bacteremia—a study of two hospitals.Proc. Roy. Soc. Med., 62, 1239 (1969).
Dietzmann, R. H., Motsay, G. I., Lillehei, R. C.: Die Anwendung von Arzneimitteln bei der Schockbehandlung.Internist 12, 103 (1971).
Gillespie, W. A., Linton, K. B., Miller, A., Slade, N.: The diagnosis, epidemiology and control of urinary infection in urology and gynaecology.J. Clin. Path. 13, 187 (1960).
Hardaway, R. M.: Syndromes of disseminated intravascular coagulation. Charles C. Thomas, Springfield, Ill. 1966.
Hardaway, R. M., James, P. M., Anderson, R. W., Bredenberg, C. E., West, R. L.: Intensive study and treatment of shock in man.J. A. M. A., 199, 779 (1967).
Hayasaka, H., Howard, J. M.: Septic shock. Charles C. Thomas, Springfield, Ill. 1964.
Hinshaw, L. B., Shanbour, L. L., Greenfield, L. J., Coalson, J. J.: Mechanism of decreased venous return.Arch. Surg. 100, 600 (1970).
Jeffries, G. H.: Liver disease associated with bacterial infections In: Cecil & Loeb's Textbook of Medicine, page 980, 12th ed. Saunders, Philadelphia and London, 1968.
Kolle, P.: Fehler und Gefahren bei endoskopischen Maßnahmen in der Urologie.Urologe 10 (1971), in print.
Lasch, H. C., Schütterle, G.: Übersichten: Niere und Hämostase.Klin. Wschr. 48, 1019 (1970).
Lillehey, R. C., Mac Lean, L. D.: Physiological approch to successful treatment of endotoxin shock in the experimental animal.Arch. Surg. 78, 464 (1959).
Mac Lean, L. D., Mulligan, W. G., Mac Lean, A. P. H., Duff, J. H.: Patterns of septic shock in man — a detailed study of 56 patients.Ann. Surg. 166, 543 (1967).
Mac Kay, D. G.: Disseminated intravascular coagulation. An intermediary mechanism of disease. Harper & Row, New York 1965.
Marston, A.: Gram-negative septicemia — clinical aspects and physiological management.Proc. roy. soc. Med. 62, 1242 (1969).
Melnick, I., Litvak, A. S.: Gram-negative bacteremia. An evaluation of 59 cases during 1963.J. Urol. (Baltimore)96, 257 (1966).
Price, D. J. E., Sleigh, J. D.: Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics.Lancet 1213 (1970).
Rabin, E. R., Graber, C. D., Vogel, E. H., Finkelstein, R. A., Tumbusch, W. A.: Fatal pseudomonas infection in burned patients.New Engl. J. Med. 265, 1225 (1961).
schimmel, E.: The hazards of hospitalisationAnn. Int. Med. 60, 100 (1964).
Schreiner, G. E., Maher, J. F.: Uremia. Charles C. Thomas, Springfield, Ill 1961.
Selden, R., Lee, S., Wang, W. L. L., Bennet, J. V., Eickhoff, T. C.: Nosocomial Klebsiella infections. Intestinal colonization as a reservoir.Ann. Int. Med., 74, 657 (1971).
Slade, N.: Bacteremia and septicemia after urological operations.Proc. roy. Soc. Med. 51, 331 (1958).
Spink, W. W.: Pathogenese und Therapie des Schocks bei Infektionen. In: Schock — ein Internationales Symposium. Springer-Verlag, Berlin-Göttingen-Heidelberg 1962.
Talbot, C. H.: Gram-negative septicemia.Proc. roy. Soc. Med. 62, 1244 (1969).
Waisbren, B. A.: Bacteremia due to gram-negative bacilli other than the salmonella.Arch. Int. Med., 88, 467 (1951).
Walter, A. M., Heilmeyer, L.: Antibiotika-Fibel 3. Auflage, Georg Thieme Verlag, Stuttgart 1969.
Weil, M. H., Shubin, H., Biddle, M.: Shock caused by gram-negative microorganisms: Analysis of 169 cases.Ann. Int. Med. 60, 384 (1964).
Weil, M. H., Shubin, H.: Diagnosis and treatment of shock. The Williams & Wilkins Co., Baltimore 1967.
Weil, M. H., Shubin, H.: The “VIP” approach to the bedside management of shock.J. A. M. A. 207, 337 (1969).
Weinstein, L., Klainer, A. S.: Management of emergencies. IV. Septic shock — pathogenesis and treatment.New Engl. J. Med. 274, 950 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Altmeyer, B., Faul, P. Iatrogenic urosepsis. International Urology and Nephrology 4, 143–151 (1972). https://doi.org/10.1007/BF02081835
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02081835