Abstract
A progressive type of immune-complex glomerulonephritis has been produced in rats by the injection of eluted gamma-globulin from kidneys of donor rats with advanced autologous immune-complex (AIC) nephritis. It is suggested that the temporary proteinuria, induced by a nephrotoxic serum, allowed the eluted gamma-globulin to come in contact with the nephritogenic antigen in the renal tubules. The mechanism which might be responsible for the development of the progressive disease is discussed.
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Barabas, A.Z., Nagi, A.H. & Lannigan, R. Induction of experimental autologous immune-complex glomerulonephritis by eluted gamma-globulin. International Urology and Nephrology 3, 283–288 (1971). https://doi.org/10.1007/BF02081767
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DOI: https://doi.org/10.1007/BF02081767