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Der freie und Gesamthistamingehalt von postmortalen Verbrennungen im Tierexperiment

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Summary

On the back skin of rats postmortal burn injuries of third degree have been induced (1, 2, 3, 6, 12, 24 hrs following decapitation), involving about 20% of the body surface. The histamine content (free and total) of the burned and intact skin have been determined by spectrofluorometric method. In the postmortal burn injuries of rats the free histamine (15.01 ± 3.67 µg/g) and the total histamine (26.0 ± 3.83 µg/g) compared to the intact scin of the same animal showed a significant rise (P < 0.001) free histamine 3,93 ± 1.65 µg/g; total histamine 8.41 ± 3.37 µg/g. In the postmortal burn injuries 57.2 ± 81.1%, in the intact skin 47.4 ± 9.0% free histamine levels have been demonstrated. As in the vital burn injuries the free histamine attained a 70.9 ± 10.3% level, such or a higher free histamine content undoubtedly proves the vital origin of the burn injury.

Zusammenfassung

Auf der Rückenhaut von Ratten wurden postmortal (1, 2, 3, 6, 12 und 24 Std nach Dekapitierung) auf 20% der Körperoberfläche ausgedehnte Verbrennungen hervorgerufen. Mit Hilfe des spektrofluorimetrischen Verfahrens bestimmten wir den freien und Gesamthistamingehalt gebrannter und unversehrter Haut.

Die nach Eintritt des Todes verursachten Brandwunden wiesen einen signifikanten Anstieg (P < 0,001) des freien Histamingehaltes (15,01 ± 3,67 µg/g) und des Gesamthistamin-gehaltes (26,0 ± 3,83 µg/g) auf im Vergleich zur unversehrten Haut desselben Tieres (freier Histamingehalt: 3,93 ± 1,65 (µg/g; Gesamthistamingehalt: 8,41 ± 3,37 µg/g). Das Niveau des freien Histamingehaltes postmortaler Verbrennungen betrug 57,2 ± 8,1% und das der unversehrten Haut 47,4 ± 9,0%. Da das freie Histamin von bei Lebzeiten entstandenen Brandwunden ein Niveau von 70,9 ± 10,3% erreicht, kann ein solcher bzw. höherer Wert des freien Histamingehaltes zweifellos als Beweis für den vitalen Ursprung der Verletzung angesehen werden.

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Authors and Affiliations

  1. Institut für gerichtlich Medizinisches der Universität Szeged, Kossuth Lajos sugárút 40, H-6724, Ungarn

    I. Gyula Fazekas, Ferenc Kosa, Erzsebet Viragos-Kis & András Basch

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  1. I. Gyula Fazekas
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  2. Ferenc Kosa
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  3. Erzsebet Viragos-Kis
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  4. András Basch
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Vorliegende Arbeit sei Prof. Dr. B. Mueller anläßlich seines 75. Geburtstages als Zeichen unserer Ehrerbietung gewidmet.

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Fazekas, I.G., Kosa, F., Viragos-Kis, E. et al. Der freie und Gesamthistamingehalt von postmortalen Verbrennungen im Tierexperiment. Z Rechtsmed 72, 213–224 (1973). https://doi.org/10.1007/BF02079409

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