European Journal of Pediatrics

, Volume 154, Issue 8, pp 610–613 | Cite as

Disproportionate growth following long-term growth hormone treatment in short children with X-linked hypophosphataemia

  • Dieter Haffner
  • Elke Wühl
  • Werner F. Blum
  • Franz Schaefer
  • Otto Mehls
Original Paper



Three short prepubertal children with X-linked hypophosphataemia were treated with 1 IU recombinant human growth hormone (rhGH)/kg per weck sc in addition to calcitriol and phosphate supplementation over a period of 3 years. Improvement of height standard deviation score (SDS) ranged from 1.0–1.7 SD based on an increase in sitting height of 1.5–2.9 SD, whereas subischial leg length improved only slightly by 0.3–0.9 SD. In all three patients, renal phosphate threshold concentration increased slightly and transient hyperparathyroidism was noted.


Treatment of stunted children with X-linked hypophosphataemia is effective in improving growth velocity, but appears to aggravate the pre-existent disporportionate stature of such children.

Key words

X-linked hypophosphataemia Short stature Growth hormone Disproportionate growth Secondary hyperparathyroidism 



glomerular filtration rate


growth hormone


recombinant human growth hormone


renal threshold phosphate concentration


X-linked hypophosphataemia


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Dieter Haffner
  • Elke Wühl
    • 1
  • Werner F. Blum
    • 1
  • Franz Schaefer
    • 1
  • Otto Mehls
    • 1
  1. 1.Sektion für Pädiatrische NephrologieUniversitäts-KinderklinikHeidelbergGermany

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